Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [(18)F]FE-PE2I-OH for Translational Dopamine Transporter Imaging

[Image: see text] Undesired radiometabolites can be detrimental to the development of positron emission tomography (PET) radioligands. Methods for quantifying radioligand metabolites in brain tissue include ex vivo studies in small animals or labeling and imaging of the radiometabolite(s) of interes...

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Detalles Bibliográficos
Autores principales: Schou, Magnus, Amini, Nahid, Takano, Akihiro, Arakawa, Ryosuke, Dahl, Kenneth, Toth, Miklos, Svedberg, Marie, Varrone, Andrea, Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587862/
https://www.ncbi.nlm.nih.gov/pubmed/37753876
http://dx.doi.org/10.1021/acschemneuro.3c00458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587862/
https://www.ncbi.nlm.nih.gov/pubmed/37753876
http://dx.doi.org/10.1021/acschemneuro.3c00458

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