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Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model

[Image: see text] In the central nervous system, some specific phosphodiesterase (PDE) isoforms modulate pathways involved in neuronal plasticity. Accumulating evidence suggests that PDE9 may be a promising therapeutic target for neurodegenerative diseases. In the current study, computational techni...

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Detalles Bibliográficos
Autores principales:	Landucci, Elisa, Ribaudo, Giovanni, Anyanwu, Margrate, Oselladore, Erika, Giannangeli, Matteo, Mazzantini, Costanza, Lana, Daniele, Giovannini, Maria Grazia, Memo, Maurizio, Pellegrini-Giampietro, Domenico E., Gianoncelli, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587872/ https://www.ncbi.nlm.nih.gov/pubmed/37726213 http://dx.doi.org/10.1021/acschemneuro.3c00431

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