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Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon

Diabetic kidney disease (DKD) is a significant complication of diabetes that requires innovative interventions to address its increasing impact. Precision medicine is a rapidly emerging paradigm that shows excellent promise in tailoring therapeutic strategies to the unique profiles of individual pat...

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Autores principales: Nageeta, FNU, Waqar, Fahad, Allahi, Ibtesam, Murtaza, Farhan, Nasir, Muhammad, Danesh, FNU, Irshad, Beena, Kumar, Rajesh, Tayyab, Arslan, Khan, Muhammad Saood Moazzam, Kumar, Satesh, Varrassi, Giustino, Khatri, Mahima, Muzammil, Muhammad Ali, Mohamad, Tamam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587911/
https://www.ncbi.nlm.nih.gov/pubmed/37868402
http://dx.doi.org/10.7759/cureus.45575
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author Nageeta, FNU
Waqar, Fahad
Allahi, Ibtesam
Murtaza, Farhan
Nasir, Muhammad
Danesh, FNU
Irshad, Beena
Kumar, Rajesh
Tayyab, Arslan
Khan, Muhammad Saood Moazzam
Kumar, Satesh
Varrassi, Giustino
Khatri, Mahima
Muzammil, Muhammad Ali
Mohamad, Tamam
author_facet Nageeta, FNU
Waqar, Fahad
Allahi, Ibtesam
Murtaza, Farhan
Nasir, Muhammad
Danesh, FNU
Irshad, Beena
Kumar, Rajesh
Tayyab, Arslan
Khan, Muhammad Saood Moazzam
Kumar, Satesh
Varrassi, Giustino
Khatri, Mahima
Muzammil, Muhammad Ali
Mohamad, Tamam
author_sort Nageeta, FNU
collection PubMed
description Diabetic kidney disease (DKD) is a significant complication of diabetes that requires innovative interventions to address its increasing impact. Precision medicine is a rapidly emerging paradigm that shows excellent promise in tailoring therapeutic strategies to the unique profiles of individual patients. This abstract examines the potential of precision medicine in managing DKD. It explores the genetic and molecular foundations, identifies biomarkers for risk assessment, provides insights into pharmacogenomics, and discusses targeted therapies. Integrating omics data and data analytics provides a comprehensive landscape for making informed decisions. The abstract highlights the difficulties encountered during the clinical implementation process, the ethical factors to be considered, and the importance of involving patients. In addition, it showcases case studies that demonstrate the effectiveness of precision-based interventions. As the field progresses, the abstract anticipates a future characterized by the integration of artificial intelligence in diagnostics and treatment. It highlights the significant impact that precision medicine can have in revolutionizing the provision of care for DKD.
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spelling pubmed-105879112023-10-21 Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon Nageeta, FNU Waqar, Fahad Allahi, Ibtesam Murtaza, Farhan Nasir, Muhammad Danesh, FNU Irshad, Beena Kumar, Rajesh Tayyab, Arslan Khan, Muhammad Saood Moazzam Kumar, Satesh Varrassi, Giustino Khatri, Mahima Muzammil, Muhammad Ali Mohamad, Tamam Cureus Endocrinology/Diabetes/Metabolism Diabetic kidney disease (DKD) is a significant complication of diabetes that requires innovative interventions to address its increasing impact. Precision medicine is a rapidly emerging paradigm that shows excellent promise in tailoring therapeutic strategies to the unique profiles of individual patients. This abstract examines the potential of precision medicine in managing DKD. It explores the genetic and molecular foundations, identifies biomarkers for risk assessment, provides insights into pharmacogenomics, and discusses targeted therapies. Integrating omics data and data analytics provides a comprehensive landscape for making informed decisions. The abstract highlights the difficulties encountered during the clinical implementation process, the ethical factors to be considered, and the importance of involving patients. In addition, it showcases case studies that demonstrate the effectiveness of precision-based interventions. As the field progresses, the abstract anticipates a future characterized by the integration of artificial intelligence in diagnostics and treatment. It highlights the significant impact that precision medicine can have in revolutionizing the provision of care for DKD. Cureus 2023-09-19 /pmc/articles/PMC10587911/ /pubmed/37868402 http://dx.doi.org/10.7759/cureus.45575 Text en Copyright © 2023, Nageeta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Nageeta, FNU
Waqar, Fahad
Allahi, Ibtesam
Murtaza, Farhan
Nasir, Muhammad
Danesh, FNU
Irshad, Beena
Kumar, Rajesh
Tayyab, Arslan
Khan, Muhammad Saood Moazzam
Kumar, Satesh
Varrassi, Giustino
Khatri, Mahima
Muzammil, Muhammad Ali
Mohamad, Tamam
Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon
title Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon
title_full Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon
title_fullStr Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon
title_full_unstemmed Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon
title_short Precision Medicine Approaches to Diabetic Kidney Disease: Personalized Interventions on the Horizon
title_sort precision medicine approaches to diabetic kidney disease: personalized interventions on the horizon
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587911/
https://www.ncbi.nlm.nih.gov/pubmed/37868402
http://dx.doi.org/10.7759/cureus.45575
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