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Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment

PURPOSE: Pancreatic cancer is one of the most aggressive malignant tumors with poor prognosis. High‐intensity focused ultrasound (HIFU) is an effective and safe treatment option for advanced pancreatic cancer, however, the survival time of patients after the treatment was different. So, the purpose...

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Autores principales: Yang, Yu, Shi, Xian‐quan, Chen, Guang, Qian, Lin‐xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587952/
https://www.ncbi.nlm.nih.gov/pubmed/37792639
http://dx.doi.org/10.1002/cam4.6568
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author Yang, Yu
Shi, Xian‐quan
Chen, Guang
Qian, Lin‐xue
author_facet Yang, Yu
Shi, Xian‐quan
Chen, Guang
Qian, Lin‐xue
author_sort Yang, Yu
collection PubMed
description PURPOSE: Pancreatic cancer is one of the most aggressive malignant tumors with poor prognosis. High‐intensity focused ultrasound (HIFU) is an effective and safe treatment option for advanced pancreatic cancer, however, the survival time of patients after the treatment was different. So, the purpose of this study was to evaluate the relationship between the high‐risk characteristics and prognosis of unresectable pancreatic cancer after HIFU treatment. PATIENTS AND METHODS: This prospective study included 30 patients with unresectable pancreatic cancer who received HIFU at Beijing Friendship Hospital. Data on patients' tumor size, pain scores, peripheral blood lymphocyte subsets, CA19‐9 and contrast enhanced ultrasound (CEUS) features were collected to assess the relationship with overall survival (OS) after HIFU. RESULTS: The median OS from the start of HIFU treatment was 159 days, 95% confidence interval (95% CI): 108–210. The levels of pain were determined by visual analogue scale (VAS) score, and the quartile of the score decreased from 6 (2, 7) to 4 (2, 5) immediately after one session of the treatment (p = 0.001). The diagnostic model showed that high post VAS score and decreasing of peripheral CD4(+) T cells were significantly correlated with poor prognosis (p < 0.05), and showed good discrimination ability (AUC = 0.848, 95% CI = 0.709–0.987). CONCLUSION: HIFU can effectively relieve pain in patients with unresectable pancreatic cancer. Post treatment VAS and change of peripheral CD4(+) T cells are independent risk factors affecting the prognosis in patients with unresectable pancreatic cancer after HIFU treatment.
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spelling pubmed-105879522023-10-21 Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment Yang, Yu Shi, Xian‐quan Chen, Guang Qian, Lin‐xue Cancer Med RESEARCH ARTICLES PURPOSE: Pancreatic cancer is one of the most aggressive malignant tumors with poor prognosis. High‐intensity focused ultrasound (HIFU) is an effective and safe treatment option for advanced pancreatic cancer, however, the survival time of patients after the treatment was different. So, the purpose of this study was to evaluate the relationship between the high‐risk characteristics and prognosis of unresectable pancreatic cancer after HIFU treatment. PATIENTS AND METHODS: This prospective study included 30 patients with unresectable pancreatic cancer who received HIFU at Beijing Friendship Hospital. Data on patients' tumor size, pain scores, peripheral blood lymphocyte subsets, CA19‐9 and contrast enhanced ultrasound (CEUS) features were collected to assess the relationship with overall survival (OS) after HIFU. RESULTS: The median OS from the start of HIFU treatment was 159 days, 95% confidence interval (95% CI): 108–210. The levels of pain were determined by visual analogue scale (VAS) score, and the quartile of the score decreased from 6 (2, 7) to 4 (2, 5) immediately after one session of the treatment (p = 0.001). The diagnostic model showed that high post VAS score and decreasing of peripheral CD4(+) T cells were significantly correlated with poor prognosis (p < 0.05), and showed good discrimination ability (AUC = 0.848, 95% CI = 0.709–0.987). CONCLUSION: HIFU can effectively relieve pain in patients with unresectable pancreatic cancer. Post treatment VAS and change of peripheral CD4(+) T cells are independent risk factors affecting the prognosis in patients with unresectable pancreatic cancer after HIFU treatment. John Wiley and Sons Inc. 2023-10-04 /pmc/articles/PMC10587952/ /pubmed/37792639 http://dx.doi.org/10.1002/cam4.6568 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Yang, Yu
Shi, Xian‐quan
Chen, Guang
Qian, Lin‐xue
Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
title Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
title_full Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
title_fullStr Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
title_full_unstemmed Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
title_short Risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
title_sort risk factors for unresectable pancreatic cancer following high‐intensity focused ultrasound treatment
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587952/
https://www.ncbi.nlm.nih.gov/pubmed/37792639
http://dx.doi.org/10.1002/cam4.6568
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