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Distribution of sentinel nodes from parotid tumors–A feasibility study

BACKGROUND: Optimum management of the N0 neck is unresolved in parotid salivary gland cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis and its´ clinical use is increasing for head and neck tumors. The object of this study was to establish whether the technique...

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Autores principales: Hammarstedt‐Nordenvall, Lalle, Bark, Rusana, Elliot, Alexandra, Von Beckerath, Mathias, Gahm, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587971/
https://www.ncbi.nlm.nih.gov/pubmed/37776164
http://dx.doi.org/10.1002/cam4.6612
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author Hammarstedt‐Nordenvall, Lalle
Bark, Rusana
Elliot, Alexandra
Von Beckerath, Mathias
Gahm, Caroline
author_facet Hammarstedt‐Nordenvall, Lalle
Bark, Rusana
Elliot, Alexandra
Von Beckerath, Mathias
Gahm, Caroline
author_sort Hammarstedt‐Nordenvall, Lalle
collection PubMed
description BACKGROUND: Optimum management of the N0 neck is unresolved in parotid salivary gland cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis and its´ clinical use is increasing for head and neck tumors. The object of this study was to establish whether the technique is applicable to detect distribution of sentinel nodes for parotid tumors. MATERIALS AND METHODS: Prosepective observational study in 30 patients with benign or low‐grade T1‐T2N0 malignant tumors in the parotid gland planned for surgical treatment. Distribution of SN was detected with a preoperative ultrasound‐guided peritumoral injection with a technetium‐99 (Tc‐99 m) laballed tracer followed by a SPECT–CT and intraoperative measurement in the neck and parotidal tissue. In patients with cytologically suspected malignant tumor or highly unclerar cytology, SNB was also performed. RESULTS: Sentinel nodes (SNs) were detected in 26/30 cases. Out of these, 7 presented with only one SN, whereas multiple sentinel nodes where detected in 19 cases. No SNs were found in neck level 1. SN was detected in level 5 independent of tumor location within the parotid gland. An intraparotidal distribution of SNs was more frequent in larger tumors. CONCLUSIONS: The use of SN‐technique in the planning of surgical treatment of parotid tumors seems feasible. It may be of clinical value for patients with parotid cancer to enable a more accurate staging and to detect occult metastasis in the SNs within the parotid as well as in the neck, enabaling the possibility to surgically remove all positive SNs at primary surgery and with reduced surgical morbidity.
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spelling pubmed-105879712023-10-21 Distribution of sentinel nodes from parotid tumors–A feasibility study Hammarstedt‐Nordenvall, Lalle Bark, Rusana Elliot, Alexandra Von Beckerath, Mathias Gahm, Caroline Cancer Med RESEARCH ARTICLES BACKGROUND: Optimum management of the N0 neck is unresolved in parotid salivary gland cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis and its´ clinical use is increasing for head and neck tumors. The object of this study was to establish whether the technique is applicable to detect distribution of sentinel nodes for parotid tumors. MATERIALS AND METHODS: Prosepective observational study in 30 patients with benign or low‐grade T1‐T2N0 malignant tumors in the parotid gland planned for surgical treatment. Distribution of SN was detected with a preoperative ultrasound‐guided peritumoral injection with a technetium‐99 (Tc‐99 m) laballed tracer followed by a SPECT–CT and intraoperative measurement in the neck and parotidal tissue. In patients with cytologically suspected malignant tumor or highly unclerar cytology, SNB was also performed. RESULTS: Sentinel nodes (SNs) were detected in 26/30 cases. Out of these, 7 presented with only one SN, whereas multiple sentinel nodes where detected in 19 cases. No SNs were found in neck level 1. SN was detected in level 5 independent of tumor location within the parotid gland. An intraparotidal distribution of SNs was more frequent in larger tumors. CONCLUSIONS: The use of SN‐technique in the planning of surgical treatment of parotid tumors seems feasible. It may be of clinical value for patients with parotid cancer to enable a more accurate staging and to detect occult metastasis in the SNs within the parotid as well as in the neck, enabaling the possibility to surgically remove all positive SNs at primary surgery and with reduced surgical morbidity. John Wiley and Sons Inc. 2023-09-30 /pmc/articles/PMC10587971/ /pubmed/37776164 http://dx.doi.org/10.1002/cam4.6612 Text en © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Hammarstedt‐Nordenvall, Lalle
Bark, Rusana
Elliot, Alexandra
Von Beckerath, Mathias
Gahm, Caroline
Distribution of sentinel nodes from parotid tumors–A feasibility study
title Distribution of sentinel nodes from parotid tumors–A feasibility study
title_full Distribution of sentinel nodes from parotid tumors–A feasibility study
title_fullStr Distribution of sentinel nodes from parotid tumors–A feasibility study
title_full_unstemmed Distribution of sentinel nodes from parotid tumors–A feasibility study
title_short Distribution of sentinel nodes from parotid tumors–A feasibility study
title_sort distribution of sentinel nodes from parotid tumors–a feasibility study
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587971/
https://www.ncbi.nlm.nih.gov/pubmed/37776164
http://dx.doi.org/10.1002/cam4.6612
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