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A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity

BACKGROUND: Immunotherapy has significantly advanced cancer treatments, but many patients do not respond to it, partly due to immunosuppressive mechanisms used by tumor cells. These cells employ immunosuppressive ligands to evade detection and elimination by the immune system. Therefore, the discove...

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Detalles Bibliográficos
Autores principales:	Lee, Dong-hee, Ahn, Hyejin, Sim, Hye-In, Choi, Eunji, Choi, Seunghyun, Jo, Yunju, Yun, Bohwan, Song, Hyun Kyu, Oh, Soo Jin, Denda-Nagai, Kaori, Park, Chan-Sik, Irimura, Tatsuro, Park, Yoon, Jin, Hyung-seung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588101/ https://www.ncbi.nlm.nih.gov/pubmed/37858248 http://dx.doi.org/10.1186/s13046-023-02840-9

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