Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome

BACKGROUND: B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several studies have linked differential methylation to self-reported intakes of folate and B12, but these estimates can be imprecise, while metabolomic biomar...

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Detalles Bibliográficos
Autores principales: Costeira, Ricardo, Evangelista, Laila, Wilson, Rory, Yan, Xinyu, Hellbach, Fabian, Sinke, Lucy, Christiansen, Colette, Villicaña, Sergio, Masachs, Olatz M., Tsai, Pei-Chien, Mangino, Massimo, Menni, Cristina, Berry, Sarah E., Beekman, Marian, van Heemst, Diana, Slagboom, P. Eline, Heijmans, Bastiaan T., Suhre, Karsten, Kastenmüller, Gabi, Gieger, Christian, Peters, Annette, Small, Kerrin S., Linseisen, Jakob, Waldenberger, Melanie, Bell, Jordana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588110/
https://www.ncbi.nlm.nih.gov/pubmed/37858220
http://dx.doi.org/10.1186/s13148-023-01578-7

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