Cargando…
Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image
PURPOSE: Detecting tumor progression of glioma continues to pose a formidable challenge. The role of fibroblast activation protein (FAP) in gliomas has been demonstrated to facilitate tumor progression. Glioma-circulating biomarkers have not yet been used in clinical practice. This study seeks to ev...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588198/ https://www.ncbi.nlm.nih.gov/pubmed/37864148 http://dx.doi.org/10.1186/s12885-023-11544-4 |
_version_ | 1785123529771974656 |
---|---|
author | Yang, Xiao-song zhu, Peng Xie, Rong-Xing Chen, Peng-fei Liu, Hong Cheng, Xiao-Man Zhu, Zheng-Quan Peng, Xiao-min Liu, Hai-bin Yang, Qun-Ying Li, Jun-Qi Zhang, Ji |
author_facet | Yang, Xiao-song zhu, Peng Xie, Rong-Xing Chen, Peng-fei Liu, Hong Cheng, Xiao-Man Zhu, Zheng-Quan Peng, Xiao-min Liu, Hai-bin Yang, Qun-Ying Li, Jun-Qi Zhang, Ji |
author_sort | Yang, Xiao-song |
collection | PubMed |
description | PURPOSE: Detecting tumor progression of glioma continues to pose a formidable challenge. The role of fibroblast activation protein (FAP) in gliomas has been demonstrated to facilitate tumor progression. Glioma-circulating biomarkers have not yet been used in clinical practice. This study seeks to evaluate the feasibility of glioma detection through the utilization of a serum FAP marker. METHODS: We adopted enzyme-linked immunosorbent assay (ELISA) technique to quantify the relative FAP level of serum autoantibodies in a cohort of 87 gliomas. The correlation between preoperative serum autoantibody relative FAP levels and postoperative pathology, including molecular pathology was investigated. A series of FAP tests were conducted on 33 cases of malignant gliomas in order to ascertain their efficacy in monitoring the progression of the disease in relation to imaging observations. To validate the presence of FAP expression in tumors, immunohistochemistry was conducted on four gliomas employing a FAP-specific antibody. Additionally, the investigation encompassed the correlation between postoperative tumor burden, as assessed through volumetric analysis, and the relative FAP level of serum autoantibodies. RESULTS: A considerable proportion of gliomas exhibited a significantly increased level of serum autoantibody relative FAP level. This elevation was closely associated with both histopathology and molecular pathology, and demonstrated longitudinal fluctuations and variations corresponding to the progression of the disease The correlation between the rise in serum autoantibody relative FAP level and tumor progression and/or exacerbation of symptoms was observed. CONCLUSIONS: The measurement of serum autoantibody relative FAP level can be used to detect the disease as a valuable biomarker. The combined utilization of its detection alongside MR imaging has the potential to facilitate a more accurate and prompt diagnosis. |
format | Online Article Text |
id | pubmed-10588198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105881982023-10-21 Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image Yang, Xiao-song zhu, Peng Xie, Rong-Xing Chen, Peng-fei Liu, Hong Cheng, Xiao-Man Zhu, Zheng-Quan Peng, Xiao-min Liu, Hai-bin Yang, Qun-Ying Li, Jun-Qi Zhang, Ji BMC Cancer Research PURPOSE: Detecting tumor progression of glioma continues to pose a formidable challenge. The role of fibroblast activation protein (FAP) in gliomas has been demonstrated to facilitate tumor progression. Glioma-circulating biomarkers have not yet been used in clinical practice. This study seeks to evaluate the feasibility of glioma detection through the utilization of a serum FAP marker. METHODS: We adopted enzyme-linked immunosorbent assay (ELISA) technique to quantify the relative FAP level of serum autoantibodies in a cohort of 87 gliomas. The correlation between preoperative serum autoantibody relative FAP levels and postoperative pathology, including molecular pathology was investigated. A series of FAP tests were conducted on 33 cases of malignant gliomas in order to ascertain their efficacy in monitoring the progression of the disease in relation to imaging observations. To validate the presence of FAP expression in tumors, immunohistochemistry was conducted on four gliomas employing a FAP-specific antibody. Additionally, the investigation encompassed the correlation between postoperative tumor burden, as assessed through volumetric analysis, and the relative FAP level of serum autoantibodies. RESULTS: A considerable proportion of gliomas exhibited a significantly increased level of serum autoantibody relative FAP level. This elevation was closely associated with both histopathology and molecular pathology, and demonstrated longitudinal fluctuations and variations corresponding to the progression of the disease The correlation between the rise in serum autoantibody relative FAP level and tumor progression and/or exacerbation of symptoms was observed. CONCLUSIONS: The measurement of serum autoantibody relative FAP level can be used to detect the disease as a valuable biomarker. The combined utilization of its detection alongside MR imaging has the potential to facilitate a more accurate and prompt diagnosis. BioMed Central 2023-10-20 /pmc/articles/PMC10588198/ /pubmed/37864148 http://dx.doi.org/10.1186/s12885-023-11544-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yang, Xiao-song zhu, Peng Xie, Rong-Xing Chen, Peng-fei Liu, Hong Cheng, Xiao-Man Zhu, Zheng-Quan Peng, Xiao-min Liu, Hai-bin Yang, Qun-Ying Li, Jun-Qi Zhang, Ji Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
title | Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
title_full | Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
title_fullStr | Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
title_full_unstemmed | Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
title_short | Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
title_sort | tracking tumor alteration in glioma through serum fibroblast activation protein combined with image |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588198/ https://www.ncbi.nlm.nih.gov/pubmed/37864148 http://dx.doi.org/10.1186/s12885-023-11544-4 |
work_keys_str_mv | AT yangxiaosong trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT zhupeng trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT xierongxing trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT chenpengfei trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT liuhong trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT chengxiaoman trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT zhuzhengquan trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT pengxiaomin trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT liuhaibin trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT yangqunying trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT lijunqi trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage AT zhangji trackingtumoralterationingliomathroughserumfibroblastactivationproteincombinedwithimage |