Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer

BACKGROUND: GRP78 is a molecular chaperone protein in the endoplasmic reticulum that is involved in protein assembly and quality control, and it participates in ER stress regulation of endoplasmic reticulum stress pathways. Studies have confirmed that GRP78 gene is highly expressed in a variety of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yingying, Wang, Wenhua, Cheng, Yuemei, Yang, Yongxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588224/
https://www.ncbi.nlm.nih.gov/pubmed/37858217
http://dx.doi.org/10.1186/s40001-023-01241-0
_version_ 1785123535626174464
author Bai, Yingying
Wang, Wenhua
Cheng, Yuemei
Yang, Yongxiu
author_facet Bai, Yingying
Wang, Wenhua
Cheng, Yuemei
Yang, Yongxiu
author_sort Bai, Yingying
collection PubMed
description BACKGROUND: GRP78 is a molecular chaperone protein in the endoplasmic reticulum that is involved in protein assembly and quality control, and it participates in ER stress regulation of endoplasmic reticulum stress pathways. Studies have confirmed that GRP78 gene is highly expressed in a variety of tumors and is involved in different biological functions. PURPOSE: The present review highlights the involvement of the GRP78 gene in regulating the development of cervical cancer by promoting the proliferation and invasion of cervical cancer cells as well as by inhibiting apoptosis and promoting the Warburg effect. High expression of GRP78 is positively correlated with chemotherapy resistance in cervical cancer. GRP78 plays an anticancer role in cervical cancer by regulating autophagy and apoptosis. Mediated immune CD8 + T cells regulate tumor cell immunity and play a role in the application of the HPV vaccine. CONCLUSIONS: GRP78 plays a multifunctional role in cervical cancer and has important therapeutic and diagnostic value.
format Online
Article
Text
id pubmed-10588224
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-105882242023-10-21 Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer Bai, Yingying Wang, Wenhua Cheng, Yuemei Yang, Yongxiu Eur J Med Res Review BACKGROUND: GRP78 is a molecular chaperone protein in the endoplasmic reticulum that is involved in protein assembly and quality control, and it participates in ER stress regulation of endoplasmic reticulum stress pathways. Studies have confirmed that GRP78 gene is highly expressed in a variety of tumors and is involved in different biological functions. PURPOSE: The present review highlights the involvement of the GRP78 gene in regulating the development of cervical cancer by promoting the proliferation and invasion of cervical cancer cells as well as by inhibiting apoptosis and promoting the Warburg effect. High expression of GRP78 is positively correlated with chemotherapy resistance in cervical cancer. GRP78 plays an anticancer role in cervical cancer by regulating autophagy and apoptosis. Mediated immune CD8 + T cells regulate tumor cell immunity and play a role in the application of the HPV vaccine. CONCLUSIONS: GRP78 plays a multifunctional role in cervical cancer and has important therapeutic and diagnostic value. BioMed Central 2023-10-20 /pmc/articles/PMC10588224/ /pubmed/37858217 http://dx.doi.org/10.1186/s40001-023-01241-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Bai, Yingying
Wang, Wenhua
Cheng, Yuemei
Yang, Yongxiu
Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
title Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
title_full Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
title_fullStr Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
title_full_unstemmed Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
title_short Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer
title_sort research progress on the grp78 gene in the diagnosis, treatment and immunity of cervical cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588224/
https://www.ncbi.nlm.nih.gov/pubmed/37858217
http://dx.doi.org/10.1186/s40001-023-01241-0
work_keys_str_mv AT baiyingying researchprogressonthegrp78geneinthediagnosistreatmentandimmunityofcervicalcancer
AT wangwenhua researchprogressonthegrp78geneinthediagnosistreatmentandimmunityofcervicalcancer
AT chengyuemei researchprogressonthegrp78geneinthediagnosistreatmentandimmunityofcervicalcancer
AT yangyongxiu researchprogressonthegrp78geneinthediagnosistreatmentandimmunityofcervicalcancer

Ejemplares similares