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Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices

INTRODUCTION: Anxiety disorders continue to prevail as the most prevalent cluster of mental disorders following the COVID-19 pandemic, exhibiting substantial detrimental effects on individuals’ overall well-being and functioning. Even after a search spanning over a decade for novel anxiolytic compou...

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Autores principales: Li, Qinxi, Jia, Xiuzhen, Zhong, Qixing, Zhong, Zhihui, Wang, Yu, Tang, Cheng, Zhao, Bangcheng, Feng, Haotian, Hao, Jingyu, Zhao, Zifu, He, Jian, Zhang, Yingqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588484/
https://www.ncbi.nlm.nih.gov/pubmed/37867495
http://dx.doi.org/10.3389/fnut.2023.1273531
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author Li, Qinxi
Jia, Xiuzhen
Zhong, Qixing
Zhong, Zhihui
Wang, Yu
Tang, Cheng
Zhao, Bangcheng
Feng, Haotian
Hao, Jingyu
Zhao, Zifu
He, Jian
Zhang, Yingqian
author_facet Li, Qinxi
Jia, Xiuzhen
Zhong, Qixing
Zhong, Zhihui
Wang, Yu
Tang, Cheng
Zhao, Bangcheng
Feng, Haotian
Hao, Jingyu
Zhao, Zifu
He, Jian
Zhang, Yingqian
author_sort Li, Qinxi
collection PubMed
description INTRODUCTION: Anxiety disorders continue to prevail as the most prevalent cluster of mental disorders following the COVID-19 pandemic, exhibiting substantial detrimental effects on individuals’ overall well-being and functioning. Even after a search spanning over a decade for novel anxiolytic compounds, none have been approved, resulting in the current anxiolytic medications being effective only for a specific subset of patients. Consequently, researchers are investigating everyday nutrients as potential alternatives to conventional medicines. Our prior study analyzed the antianxiety and memory-enhancing properties of the combination of Walnut Peptide (WP) and Casein Peptide (CP) in zebrafish. METHODS AND RESULTS: Based on this work, our current research further validates their effects in mice models exhibiting elevated anxiety levels through a combination of gavage oral administration. Our results demonstrated that at 170 + 300 mg human dose, the WP + CP combination significantly improved performances in relevant behavioral assessments related to anxiety and memory. Furthermore, our analysis revealed that the combination restores neurotransmitter dysfunction observed while monitoring Serotonin, gamma-aminobutyric acid (GABA), dopamine (DA), and acetylcholine (ACh) levels. This supplementation also elevated the expression of brain-derived neurotrophic factor mRNA, indicating protective effects against the neurological stresses of anxiety. Additionally, there were strong correlations among behavioral indicators, BDNF (brain-derived neurotrophic factor), and numerous neurotransmitters. CONCLUSION: Hence, our findings propose that the WP + CP combination holds promise as a treatment for anxiety disorder. Besides, supplementary applications are feasible when produced as powdered dietary supplements or added to common foods like powder, yogurt, or milk.
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spelling pubmed-105884842023-10-21 Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices Li, Qinxi Jia, Xiuzhen Zhong, Qixing Zhong, Zhihui Wang, Yu Tang, Cheng Zhao, Bangcheng Feng, Haotian Hao, Jingyu Zhao, Zifu He, Jian Zhang, Yingqian Front Nutr Nutrition INTRODUCTION: Anxiety disorders continue to prevail as the most prevalent cluster of mental disorders following the COVID-19 pandemic, exhibiting substantial detrimental effects on individuals’ overall well-being and functioning. Even after a search spanning over a decade for novel anxiolytic compounds, none have been approved, resulting in the current anxiolytic medications being effective only for a specific subset of patients. Consequently, researchers are investigating everyday nutrients as potential alternatives to conventional medicines. Our prior study analyzed the antianxiety and memory-enhancing properties of the combination of Walnut Peptide (WP) and Casein Peptide (CP) in zebrafish. METHODS AND RESULTS: Based on this work, our current research further validates their effects in mice models exhibiting elevated anxiety levels through a combination of gavage oral administration. Our results demonstrated that at 170 + 300 mg human dose, the WP + CP combination significantly improved performances in relevant behavioral assessments related to anxiety and memory. Furthermore, our analysis revealed that the combination restores neurotransmitter dysfunction observed while monitoring Serotonin, gamma-aminobutyric acid (GABA), dopamine (DA), and acetylcholine (ACh) levels. This supplementation also elevated the expression of brain-derived neurotrophic factor mRNA, indicating protective effects against the neurological stresses of anxiety. Additionally, there were strong correlations among behavioral indicators, BDNF (brain-derived neurotrophic factor), and numerous neurotransmitters. CONCLUSION: Hence, our findings propose that the WP + CP combination holds promise as a treatment for anxiety disorder. Besides, supplementary applications are feasible when produced as powdered dietary supplements or added to common foods like powder, yogurt, or milk. Frontiers Media S.A. 2023-10-06 /pmc/articles/PMC10588484/ /pubmed/37867495 http://dx.doi.org/10.3389/fnut.2023.1273531 Text en Copyright © 2023 Li, Jia, Zhong, Zhong, Wang, Tang, Zhao, Feng, Hao, Zhao, He and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Li, Qinxi
Jia, Xiuzhen
Zhong, Qixing
Zhong, Zhihui
Wang, Yu
Tang, Cheng
Zhao, Bangcheng
Feng, Haotian
Hao, Jingyu
Zhao, Zifu
He, Jian
Zhang, Yingqian
Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
title Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
title_full Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
title_fullStr Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
title_full_unstemmed Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
title_short Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices
title_sort combination of walnut peptide and casein peptide alleviates anxiety and improves memory in anxiety mices
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588484/
https://www.ncbi.nlm.nih.gov/pubmed/37867495
http://dx.doi.org/10.3389/fnut.2023.1273531
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