Cargando…

Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis

BACKGROUND AND AIMS: Exacerbated immune activation, intestinal dysbiosis and a disrupted intestinal barrier are common features among inflammatory bowel disease [IBD] patients. The polyamine spermidine, which is naturally present in all living organisms, is an integral component of the human diet, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niechcial, Anna, Schwarzfischer, Marlene, Wawrzyniak, Marcin, Atrott, Kirstin, Laimbacher, Andrea, Morsy, Yasser, Katkeviciute, Egle, Häfliger, Janine, Westermann, Patrick, Akdis, Cezmi A, Scharl, Michael, Spalinger, Marianne R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588784/ https://www.ncbi.nlm.nih.gov/pubmed/36995738 http://dx.doi.org/10.1093/ecco-jcc/jjad058

Ejemplares similares

Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells
por: Conde, Javier, et al.
Publicado: (2021)

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N(2) in Dendritic Cells to Protect from Elevated Colitis
por: Hering, Larissa, et al.
Publicado: (2021)

Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity
por: Häfliger, Janine, et al.
Publicado: (2022)

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance
por: Hering, Larissa, et al.
Publicado: (2020)

Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis
por: Morón, Belén, et al.
Publicado: (2013)

Spermidine and spermine exert protective effects within the lung
por: Wawrzyniak, Marcin, et al.
Publicado: (2021)

The Role of Protein Tyrosine Phosphatases in Inflammasome Activation
por: Spalinger, Marianne R., et al.
Publicado: (2020)

Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer
por: Busenhart, Philipp, et al.
Publicado: (2022)

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome
por: Ruiz, Pedro A, et al.
Publicado: (2017)

Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease
por: Morsy, Yasser, et al.
Publicado: (2021)

PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation
por: Spalinger, Marianne R., et al.
Publicado: (2018)

A wide diversity of bacteria from the human gut produces and degrades biogenic amines
por: Pugin, Benoit, et al.
Publicado: (2017)

Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis
por: Roth, Sofia, et al.
Publicado: (2016)

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
por: Cosin-Roger, Jesus, et al.
Publicado: (2018)

Endothelial Barrier Disruption by Lipid Emulsions Containing a High Amount of N3 Fatty Acids (Omegaven) but Not N6 Fatty Acids (Intralipid)
por: Gueguen, Emilie, et al.
Publicado: (2022)

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
por: Spalinger, Marianne R., et al.
Publicado: (2023)

Mechanisms of immune-tolerance to allergens on the mucosal surfaces
por: Akdis, Cezmi
Publicado: (2011)

Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens
por: Akdis, Cezmi A, et al.
Publicado: (2015)

Mutant HRAS as novel target for MEK and mTOR inhibitors
por: Kiessling, Michael K., et al.
Publicado: (2015)

Nature of Regulatory T Cells in the Context of Allergic Disease
por: Ozdemir, Cevdet, et al.
Publicado: (2008)

Update in the Mechanisms of Allergen-Specific Immunotheraphy
por: Akkoc, Tunc, et al.
Publicado: (2011)

Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium
por: Stocker, Nino, et al.
Publicado: (2023)

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis
por: Raselli, Tina, et al.
Publicado: (2019)

Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy
por: Spalinger, Marianne R., et al.
Publicado: (2013)

Spermidine delays aging in humans
por: Madeo, Frank, et al.
Publicado: (2018)

Spermidine cures yeast of prions
por: Speldewinde, Shaun H., et al.
Publicado: (2015)

Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis
por: Molinero, Natalia, et al.
Publicado: (2022)

T-cell Subset Regulation in Atopy
por: Jutel, Marek, et al.
Publicado: (2011)

Stepwise Development of an in vitro Continuous Fermentation Model for the Murine Caecal Microbiota
por: Poeker, Sophie A., et al.
Publicado: (2019)

Transcriptional and Ultrastructural Analyses Suggest Novel Insights into Epithelial Barrier Impairment in Celiac Disease
por: Sowińska, Agnieszka, et al.
Publicado: (2020)

Mechanisms of allergen-specific immunotherapy
por: Fujita, Hiroyuki, et al.
Publicado: (2012)

Mechanisms of immune tolerance to allergens in children
por: Kucuksezer, Umut C., et al.
Publicado: (2013)

The Induction of IL-33 in the Sinus Epithelium and Its Influence on T-Helper Cell Responses
por: Soyka, Michael B., et al.
Publicado: (2015)

The Intestinal Barrier—Shielding the Body from Nano- and Microparticles in Our Diet
por: Schwarzfischer, Marlene, et al.
Publicado: (2022)

Human and planetary health on fire
por: Akdis, Cezmi A., et al.
Publicado: (2022)

Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis
por: Maldonado‐Arriaga, Brenda, et al.
Publicado: (2021)

Differential serum protein markers and the clinical severity of asthma
por: Meyer, Norbert, et al.
Publicado: (2014)

New roles for autophagy and spermidine in T cells
por: Puleston, D. J., et al.
Publicado: (2015)

Innate lymphoid cell subsets in obese asthma patients: Difference in activated cells in peripheral blood and their relationship to disease severity
por: Celebi Sozener, Zeynep, et al.
Publicado: (2022)

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
por: Cosin-Roger, Jesus, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0aa1tr45l8q9c9as1oav6gemuu