Cargando…

Multiomics-empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States

INTRODUCTION: Ulcerative colitis [UC] is a chronic disease with rising incidence and unclear aetiology. Deep molecular phenotyping by multiomics analyses may provide novel insights into disease processes and characteristic features of remission states. METHODS: UC pathomechanisms were assessed by pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Janker, Lukas, Schuster, Dina, Bortel, Patricia, Hagn, Gerhard, Meier-Menches, Samuel M, Mohr, Thomas, Mader, Johanna C, Slany, Astrid, Bileck, Andrea, Brunmair, Julia, Madl, Christian, Unger, Lukas, Hennlich, Barbara, Weitmayr, Barbara, Del Favero, Giorgia, Pils, Dietmar, Pukrop, Tobias, Pfisterer, Nikolaus, Feichtenschlager, Thomas, Gerner, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588787/ https://www.ncbi.nlm.nih.gov/pubmed/36961872 http://dx.doi.org/10.1093/ecco-jcc/jjad052

Ejemplares similares

Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture
por: Niederstaetter, Laura, et al.
Publicado: (2021)

Finger sweat analysis enables short interval metabolic biomonitoring in humans
por: Brunmair, Julia, et al.
Publicado: (2021)

Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients
por: Brunmair, Julia, et al.
Publicado: (2022)

Inward Outward Signaling in Ovarian Cancer: Morpho-Phospho-Proteomic Profiling Upon Application of Hypoxia and Shear Stress Characterizes the Adaptive Plasticity of OVCAR-3 and SKOV-3 Cells
por: Bileck, Andrea, et al.
Publicado: (2022)

Metabo-tip: a metabolomics platform for lifestyle monitoring supporting the development of novel strategies in predictive, preventive and personalised medicine
por: Brunmair, Julia, et al.
Publicado: (2021)

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells
por: Gerner, Marlene C., et al.
Publicado: (2019)

Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels
por: Neuditschko, Benjamin, et al.
Publicado: (2021)

An Anticancer Rhenium Tricarbonyl Targets Fe−S Cluster Biogenesis in Ovarian Cancer Cells
por: Neuditschko, Benjamin, et al.
Publicado: (2022)

A Proteomic Platform Enables to Test for AML Normalization In Vitro
por: Meier-Menches, Samuel M., et al.
Publicado: (2022)

Clinical algorithms for the prevention of variceal bleeding and rebleeding in patients with liver cirrhosis
por: Pfisterer, Nikolaus, et al.
Publicado: (2021)

Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?
por: Ribitsch, Iris, et al.
Publicado: (2021)

The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts
por: Neuditschko, Benjamin, et al.
Publicado: (2020)

Packed red blood cells inhibit T-cell activation via ROS-dependent signaling pathways
por: Gerner, Marlene C., et al.
Publicado: (2021)

Dichotomous Responses to Chronic Fetal Hypoxia Lead to a Predetermined Aging Phenotype
por: Rudloff, Stefan, et al.
Publicado: (2021)

A multi-omics based anti-inflammatory immune signature characterizes long COVID-19 syndrome
por: Kovarik, Johannes J., et al.
Publicado: (2022)

Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin
por: Seiser, Saskia, et al.
Publicado: (2021)

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function
por: Del Favero, Giorgia, et al.
Publicado: (2021)

Neutrophil Extracellular Trap Formation Correlates with Favorable Overall Survival in High Grade Ovarian Cancer
por: Muqaku, Besnik, et al.
Publicado: (2020)

Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
por: Zila, Nina, et al.
Publicado: (2018)

Perceptions on the management of varices and on the use of albumin in patients with cirrhosis among GI specialists in Austria
por: Pfisterer, Nikolaus, et al.
Publicado: (2020)

Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice
por: Fuchs, Valentin, et al.
Publicado: (2022)

Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation
por: Del Favero, Giorgia, et al.
Publicado: (2018)

Structural Similarity with Cholesterol Reveals Crucial Insights into Mechanisms Sustaining the Immunomodulatory Activity of the Mycotoxin Alternariol
por: Del Favero, Giorgia, et al.
Publicado: (2020)

Endoscopic band ligation is safe despite low platelet count and high INR
por: Pfisterer, Nikolaus, et al.
Publicado: (2023)

Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer
por: Zappe, Katja, et al.
Publicado: (2023)

Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
por: Weiss, Tamara, et al.
Publicado: (2021)

VP2: Schwann Cells Regulate Neuronal Differentiation by Epidermal Growth Factor-Like Protein 8
por: Weiss, Tamara, et al.
Publicado: (2022)

Outcomes after placement of a SX‐ELLA oesophageal stent for refractory variceal bleeding—A national multicentre study
por: Pfisterer, Nikolaus, et al.
Publicado: (2018)

Exposure to dietary fatty acids oleic and palmitic acid alters structure and mechanotransduction of intestinal cells in vitro
por: Bergen, Janice, et al.
Publicado: (2023)

Metabolomics implicate eicosanoids in severe functional mitral regurgitation
por: Hofbauer, Thomas M., et al.
Publicado: (2022)

Hepatic Steatosis in Lean Patients: Risk Factors and Impact on Mortality
por: Unger, Lukas W., et al.
Publicado: (2019)

Probabilistic quotient’s work and pharmacokinetics’ contribution: countering size effect in metabolic time series measurements
por: Gotsmy, Mathias, et al.
Publicado: (2022)

INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage
por: Leitner, Gerda C., et al.
Publicado: (2022)

Multiomics tools for the diagnosis and treatment of rare neurological disease
por: Crowther, L. M., et al.
Publicado: (2018)

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer
por: Unterleuthner, Daniela, et al.
Publicado: (2019)

The Essentials of Multiomics
por: Marshall, John L, et al.
Publicado: (2022)

Tyk2 is a tumor suppressor in colorectal cancer
por: Moritsch, Stefan, et al.
Publicado: (2022)

An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
por: Meier‐Menches, Samuel M., et al.
Publicado: (2020)

Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis
por: Mohr, Thomas, et al.
Publicado: (2017)

IDARE2—Simultaneous Visualisation of Multiomics Data in Cytoscape
por: Pfau, Thomas, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_murlvd1mdh07m9d986mkc6d1hj