Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance

Lipopolysaccharide (LPS) derived from Porphyromonas gingivalis (P.g.), which causes periodontal disease, contributes to the development of non-alcoholic steatohepatitis (NASH). We investigated the role of Nrf2, an antioxidative stress sensor, in macrophages in the development of NASH induced by LPS...

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Detalles Bibliográficos
Autores principales: Chihara, Kanako, Okada, Kosuke, Uchida, Fumihiko, Miura, Ikuru, Komine, Shoichi, Warabi, Eiji, Takayama, Takako, Suzuki, Hideo, Matsuzaka, Takashi, Ishibashi-Kanno, Naomi, Yamagata, Kenji, Yanagawa, Toru, Bukawa, Hiroki, Shoda, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588835/
https://www.ncbi.nlm.nih.gov/pubmed/37862331
http://dx.doi.org/10.1371/journal.pone.0291880

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