ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

BACKGROUND: Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed to determine whether ACE inhibition would reduce...

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Detalles Bibliográficos
Autores principales: Rossios, Christos, Bashir, Tufail, Achison, Marcus, Adamson, Simon, Akpan, Asangaedem, Aspray, Terry, Avenell, Alison, Band, Margaret M., Burton, Louise A., Cvoro, Vera, Donnan, Peter T., Duncan, Gordon W., George, Jacob, Gordon, Adam L., Gregson, Celia L., Hapca, Adrian, Hume, Cheryl, Jackson, Thomas A., Kerr, Simon, Kilgour, Alixe, Masud, Tahir, McKenzie, Andrew, McKenzie, Emma, Patel, Harnish, Pilvinyte, Kristina, Roberts, Helen C., Sayer, Avan A., Smith, Karen T., Soiza, Roy L., Steves, Claire J., Struthers, Allan D., Tiwari, Divya, Whitney, Julie, Witham, Miles D., Kemp, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588903/
https://www.ncbi.nlm.nih.gov/pubmed/37862321
http://dx.doi.org/10.1371/journal.pone.0292402

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