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CHEK2 signaling is the key regulator of oocyte survival after chemotherapy

Cancer treatments can damage the ovarian follicle reserve, leading to primary ovarian insufficiency and infertility among survivors. Checkpoint kinase 2 (CHEK2) deficiency prevents elimination of oocytes in primordial follicles in female mice exposed to radiation and preserves their ovarian function...

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Detalles Bibliográficos
Autores principales: Emori, Chihiro, Boucher, Zachary, Bolcun-Filas, Ewelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588956/
https://www.ncbi.nlm.nih.gov/pubmed/37862420
http://dx.doi.org/10.1126/sciadv.adg0898