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Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab

Autoimmune lupus enteritis in systemic lupus erythematosus (SLE) is a rare manifestation that comprises of gastrointestinal tract inflammation with supportive images and/or biopsy findings. We report a unique case of widespread lupus enteritis occurring late in the disease process and in isolation w...

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Autores principales: Shaik, Mohammed R., Shaik, Nishat A., Huang, Yuting, Pandey, Ankur, Wheeler, Erika, Mikdashi, Jamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Greater Baltimore Medical Center 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589013/
https://www.ncbi.nlm.nih.gov/pubmed/37868240
http://dx.doi.org/10.55729/2000-9666.1185
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author Shaik, Mohammed R.
Shaik, Nishat A.
Huang, Yuting
Pandey, Ankur
Wheeler, Erika
Mikdashi, Jamal
author_facet Shaik, Mohammed R.
Shaik, Nishat A.
Huang, Yuting
Pandey, Ankur
Wheeler, Erika
Mikdashi, Jamal
author_sort Shaik, Mohammed R.
collection PubMed
description Autoimmune lupus enteritis in systemic lupus erythematosus (SLE) is a rare manifestation that comprises of gastrointestinal tract inflammation with supportive images and/or biopsy findings. We report a unique case of widespread lupus enteritis occurring late in the disease process and in isolation without additional features of active SLE but in the presence of SLE serological activity. There was no clear evidence of active mesenteric vasculitis, intestinal pseudo-obstruction, protein-losing enteropathy, or coagulopathy by imaging or histopathology. This is the first reported case of an SLE patient with pan-gastrointestinal involvement of lupus enteritis responding to Belimumab, with complete resolution of the gastrointestinal syndrome and no further recurrence of gastrointestinal events. Rapid diagnosis and prompt immunomodulatory treatment of lupus-related enteritis are critical to avoid potentially life-threatening complications.
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spelling pubmed-105890132023-10-21 Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab Shaik, Mohammed R. Shaik, Nishat A. Huang, Yuting Pandey, Ankur Wheeler, Erika Mikdashi, Jamal J Community Hosp Intern Med Perspect Case Report Autoimmune lupus enteritis in systemic lupus erythematosus (SLE) is a rare manifestation that comprises of gastrointestinal tract inflammation with supportive images and/or biopsy findings. We report a unique case of widespread lupus enteritis occurring late in the disease process and in isolation without additional features of active SLE but in the presence of SLE serological activity. There was no clear evidence of active mesenteric vasculitis, intestinal pseudo-obstruction, protein-losing enteropathy, or coagulopathy by imaging or histopathology. This is the first reported case of an SLE patient with pan-gastrointestinal involvement of lupus enteritis responding to Belimumab, with complete resolution of the gastrointestinal syndrome and no further recurrence of gastrointestinal events. Rapid diagnosis and prompt immunomodulatory treatment of lupus-related enteritis are critical to avoid potentially life-threatening complications. Greater Baltimore Medical Center 2023-06-29 /pmc/articles/PMC10589013/ /pubmed/37868240 http://dx.doi.org/10.55729/2000-9666.1185 Text en © 2023 Greater Baltimore Medical Center https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ).
spellingShingle Case Report
Shaik, Mohammed R.
Shaik, Nishat A.
Huang, Yuting
Pandey, Ankur
Wheeler, Erika
Mikdashi, Jamal
Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab
title Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab
title_full Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab
title_fullStr Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab
title_full_unstemmed Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab
title_short Autoimmune Lupus Enteritis with Pan Gastrointestinal Involvement in an Adult Patient with Systemic Lupus Erythematosus: Complete Response to Belimumab
title_sort autoimmune lupus enteritis with pan gastrointestinal involvement in an adult patient with systemic lupus erythematosus: complete response to belimumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589013/
https://www.ncbi.nlm.nih.gov/pubmed/37868240
http://dx.doi.org/10.55729/2000-9666.1185
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