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Permission to pass: on the role of p53 as a gatekeeper for aneuploidy

Aneuploidy—the karyotype state in which the number of chromosomes deviates from a multiple of the haploid chromosome set—is common in cancer, where it is thought to facilitate tumor initiation and progression. However, it is poorly tolerated in healthy cells: during development and tissue homeostasi...

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Autores principales: Marques, Joana F., Kops, Geert J. P. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589155/
https://www.ncbi.nlm.nih.gov/pubmed/37864038
http://dx.doi.org/10.1007/s10577-023-09741-9
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author Marques, Joana F.
Kops, Geert J. P. L.
author_facet Marques, Joana F.
Kops, Geert J. P. L.
author_sort Marques, Joana F.
collection PubMed
description Aneuploidy—the karyotype state in which the number of chromosomes deviates from a multiple of the haploid chromosome set—is common in cancer, where it is thought to facilitate tumor initiation and progression. However, it is poorly tolerated in healthy cells: during development and tissue homeostasis, aneuploid cells are efficiently cleared from the population. It is still largely unknown how cancer cells become, and adapt to being, aneuploid. P53, the gatekeeper of the genome, has been proposed to guard against aneuploidy. Aneuploidy in cancer genomes strongly correlates with mutations in TP53, and p53 is thought to prevent the propagation of aneuploid cells. Whether p53 also participates in preventing the mistakes in cell division that lead to aneuploidy is still under debate. In this review, we summarize the current understanding of the role of p53 in protecting cells from aneuploidy, and we explore the consequences of functional p53 loss for the propagation of aneuploidy in cancer.
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spelling pubmed-105891552023-10-22 Permission to pass: on the role of p53 as a gatekeeper for aneuploidy Marques, Joana F. Kops, Geert J. P. L. Chromosome Res Review Aneuploidy—the karyotype state in which the number of chromosomes deviates from a multiple of the haploid chromosome set—is common in cancer, where it is thought to facilitate tumor initiation and progression. However, it is poorly tolerated in healthy cells: during development and tissue homeostasis, aneuploid cells are efficiently cleared from the population. It is still largely unknown how cancer cells become, and adapt to being, aneuploid. P53, the gatekeeper of the genome, has been proposed to guard against aneuploidy. Aneuploidy in cancer genomes strongly correlates with mutations in TP53, and p53 is thought to prevent the propagation of aneuploid cells. Whether p53 also participates in preventing the mistakes in cell division that lead to aneuploidy is still under debate. In this review, we summarize the current understanding of the role of p53 in protecting cells from aneuploidy, and we explore the consequences of functional p53 loss for the propagation of aneuploidy in cancer. Springer Netherlands 2023-10-21 2023 /pmc/articles/PMC10589155/ /pubmed/37864038 http://dx.doi.org/10.1007/s10577-023-09741-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Marques, Joana F.
Kops, Geert J. P. L.
Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
title Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
title_full Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
title_fullStr Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
title_full_unstemmed Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
title_short Permission to pass: on the role of p53 as a gatekeeper for aneuploidy
title_sort permission to pass: on the role of p53 as a gatekeeper for aneuploidy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589155/
https://www.ncbi.nlm.nih.gov/pubmed/37864038
http://dx.doi.org/10.1007/s10577-023-09741-9
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