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Opportunities and challenges of microbial siderophores in the medical field

Siderophores are low-molecular-weight secondary metabolites that function as iron chelators. Under iron-deficiency conditions, they are produced by a wide variety of microbes, allowing them to increase their iron uptake. The primary function of these compounds is the environmental iron scavenging an...

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Autores principales: Passari, Ajit Kumar, Ruiz-Villafán, Beatriz, Cruz-Bautista, Rodrigo, Díaz-Domínguez, Valerie, Rodríguez-Sanoja, Romina, Sanchez, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589192/
https://www.ncbi.nlm.nih.gov/pubmed/37755507
http://dx.doi.org/10.1007/s00253-023-12742-7
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author Passari, Ajit Kumar
Ruiz-Villafán, Beatriz
Cruz-Bautista, Rodrigo
Díaz-Domínguez, Valerie
Rodríguez-Sanoja, Romina
Sanchez, Sergio
author_facet Passari, Ajit Kumar
Ruiz-Villafán, Beatriz
Cruz-Bautista, Rodrigo
Díaz-Domínguez, Valerie
Rodríguez-Sanoja, Romina
Sanchez, Sergio
author_sort Passari, Ajit Kumar
collection PubMed
description Siderophores are low-molecular-weight secondary metabolites that function as iron chelators. Under iron-deficiency conditions, they are produced by a wide variety of microbes, allowing them to increase their iron uptake. The primary function of these compounds is the environmental iron scavenging and its transport into the cytosol. Iron is then reduced to its ferrous form to operate as an enzymatic cofactor for various functions, including respiration, nitrogen fixation, photosynthesis, methanogenesis, and amino acid synthesis. Depending on their functional group, siderophores are classified into hydroxamate, catecholate, phenolate, carboxylate, and mixed types. They have achieved great importance in recent years due to their medical applications as antimicrobial, antimalarial, or anticancer drugs, vaccines, and drug-delivery agents. This review integrates current advances in specific healthcare applications of microbial siderophores, delineating new opportunities and challenges as viable therapies to fight against diseases that represent crucial public health problems in the medical field. Key points • Siderophores are low-molecular-weight secondary metabolites functioning as iron chelators. • The siderophore’s properties offer viable options to face diverse clinical problems. • Siderophores are alternatives for the enhancement of antibiotic activities.
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spelling pubmed-105891922023-10-22 Opportunities and challenges of microbial siderophores in the medical field Passari, Ajit Kumar Ruiz-Villafán, Beatriz Cruz-Bautista, Rodrigo Díaz-Domínguez, Valerie Rodríguez-Sanoja, Romina Sanchez, Sergio Appl Microbiol Biotechnol Mini-Review Siderophores are low-molecular-weight secondary metabolites that function as iron chelators. Under iron-deficiency conditions, they are produced by a wide variety of microbes, allowing them to increase their iron uptake. The primary function of these compounds is the environmental iron scavenging and its transport into the cytosol. Iron is then reduced to its ferrous form to operate as an enzymatic cofactor for various functions, including respiration, nitrogen fixation, photosynthesis, methanogenesis, and amino acid synthesis. Depending on their functional group, siderophores are classified into hydroxamate, catecholate, phenolate, carboxylate, and mixed types. They have achieved great importance in recent years due to their medical applications as antimicrobial, antimalarial, or anticancer drugs, vaccines, and drug-delivery agents. This review integrates current advances in specific healthcare applications of microbial siderophores, delineating new opportunities and challenges as viable therapies to fight against diseases that represent crucial public health problems in the medical field. Key points • Siderophores are low-molecular-weight secondary metabolites functioning as iron chelators. • The siderophore’s properties offer viable options to face diverse clinical problems. • Siderophores are alternatives for the enhancement of antibiotic activities. Springer Berlin Heidelberg 2023-09-27 2023 /pmc/articles/PMC10589192/ /pubmed/37755507 http://dx.doi.org/10.1007/s00253-023-12742-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mini-Review
Passari, Ajit Kumar
Ruiz-Villafán, Beatriz
Cruz-Bautista, Rodrigo
Díaz-Domínguez, Valerie
Rodríguez-Sanoja, Romina
Sanchez, Sergio
Opportunities and challenges of microbial siderophores in the medical field
title Opportunities and challenges of microbial siderophores in the medical field
title_full Opportunities and challenges of microbial siderophores in the medical field
title_fullStr Opportunities and challenges of microbial siderophores in the medical field
title_full_unstemmed Opportunities and challenges of microbial siderophores in the medical field
title_short Opportunities and challenges of microbial siderophores in the medical field
title_sort opportunities and challenges of microbial siderophores in the medical field
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589192/
https://www.ncbi.nlm.nih.gov/pubmed/37755507
http://dx.doi.org/10.1007/s00253-023-12742-7
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