A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity

Dysregulation of pathogen-recognition pathways of the innate immune system is associated with multiple autoimmune disorders. Due to the intricacies of the molecular network involved, the identification of pathway- and disease-specific therapeutics has been challenging. Using a phenotypic assay monit...

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Detalles Bibliográficos
Autores principales: Boeszoermenyi, Andras, Bernaleau, Léa, Chen, Xudong, Kartnig, Felix, Xie, Min, Zhang, Haobo, Zhang, Sensen, Delacrétaz, Maeva, Koren, Anna, Hopp, Ann-Katrin, Dvorak, Vojtech, Kubicek, Stefan, Aletaha, Daniel, Yang, Maojun, Rebsamen, Manuele, Heinz, Leonhard X., Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589233/
https://www.ncbi.nlm.nih.gov/pubmed/37863876
http://dx.doi.org/10.1038/s41467-023-42070-3

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