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Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens

Synthetic lethality offers a promising approach for developing effective therapeutic interventions in cancer when direct targeting of driver genes is impractical. In this study, we comprehensively analyzed large-scale CRISPR, shRNA, and PRISM screens to identify potential synthetic lethal (SL) inter...

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Detalles Bibliográficos
Autores principales:	Karimpour, Mina, Totonchi, Mehdi, Behmanesh, Mehrdad, Montazeri, Hesam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2023
Materias:	Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589366/ https://www.ncbi.nlm.nih.gov/pubmed/37863651 http://dx.doi.org/10.26508/lsa.202302268

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