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Treatment of a life-threatening dapsone intoxication

The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, asc...

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Detalles Bibliográficos
Autores principales: Veerman, M.H., van Gelder, T., Sneijder, R., Bethlehem, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589372/
https://www.ncbi.nlm.nih.gov/pubmed/37868805
http://dx.doi.org/10.1016/j.toxrep.2023.10.006
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author Veerman, M.H.
van Gelder, T.
Sneijder, R.
Bethlehem, C.
author_facet Veerman, M.H.
van Gelder, T.
Sneijder, R.
Bethlehem, C.
author_sort Veerman, M.H.
collection PubMed
description The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, ascorbic acid, folinic acid, multidose activated charcoal and hemodialysis. Measurements of blood gases, dapsone and methotrexate levels were performed. Furthermore a hepatitis, pulmonary artery thrombus and a strange taste sensation were diagnosed, probably related to dapsone. The patient recovered and was discharged from hospital after five days. Acute intoxication from excessive dapsone intake is uncommon and clear treatment guidelines are lacking. We here report the treatment modalities as a result of a dapsone intoxication, including the effects on the overall condition of the patient.
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spelling pubmed-105893722023-10-22 Treatment of a life-threatening dapsone intoxication Veerman, M.H. van Gelder, T. Sneijder, R. Bethlehem, C. Toxicol Rep Article The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, ascorbic acid, folinic acid, multidose activated charcoal and hemodialysis. Measurements of blood gases, dapsone and methotrexate levels were performed. Furthermore a hepatitis, pulmonary artery thrombus and a strange taste sensation were diagnosed, probably related to dapsone. The patient recovered and was discharged from hospital after five days. Acute intoxication from excessive dapsone intake is uncommon and clear treatment guidelines are lacking. We here report the treatment modalities as a result of a dapsone intoxication, including the effects on the overall condition of the patient. Elsevier 2023-10-13 /pmc/articles/PMC10589372/ /pubmed/37868805 http://dx.doi.org/10.1016/j.toxrep.2023.10.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Veerman, M.H.
van Gelder, T.
Sneijder, R.
Bethlehem, C.
Treatment of a life-threatening dapsone intoxication
title Treatment of a life-threatening dapsone intoxication
title_full Treatment of a life-threatening dapsone intoxication
title_fullStr Treatment of a life-threatening dapsone intoxication
title_full_unstemmed Treatment of a life-threatening dapsone intoxication
title_short Treatment of a life-threatening dapsone intoxication
title_sort treatment of a life-threatening dapsone intoxication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589372/
https://www.ncbi.nlm.nih.gov/pubmed/37868805
http://dx.doi.org/10.1016/j.toxrep.2023.10.006
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