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Merkel cell polyomavirus and its etiological relationship with skin tumors()

Viruses have been frequently identified in several human neoplasms, but the etiological role of these viruses in some tumors is still a matter of controversy. Polyomaviruses stand out among the main viruses with oncogenic capacity, specifically the Merkel cell polyomavirus (MCPyV). Recent revisions...

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Autores principales: Bellott, Thiago Rubim, Luz, Flávio Barbosa, Silva, Anna Karoline Fausto da, Varella, Rafael Brandão, Rochael, Mayra Carrijo, Pantaleão, Luciana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589487/
https://www.ncbi.nlm.nih.gov/pubmed/37407331
http://dx.doi.org/10.1016/j.abd.2023.04.004
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author Bellott, Thiago Rubim
Luz, Flávio Barbosa
Silva, Anna Karoline Fausto da
Varella, Rafael Brandão
Rochael, Mayra Carrijo
Pantaleão, Luciana
author_facet Bellott, Thiago Rubim
Luz, Flávio Barbosa
Silva, Anna Karoline Fausto da
Varella, Rafael Brandão
Rochael, Mayra Carrijo
Pantaleão, Luciana
author_sort Bellott, Thiago Rubim
collection PubMed
description Viruses have been frequently identified in several human neoplasms, but the etiological role of these viruses in some tumors is still a matter of controversy. Polyomaviruses stand out among the main viruses with oncogenic capacity, specifically the Merkel cell polyomavirus (MCPyV). Recent revisions in the taxonomy of polyomaviruses have divided the Polyomaviridae family into six genera, including 117 species, with a total of 14 currently known human-infecting species. Although the oncogenicity of polyomaviruses has been widely reported in the literature since 1950, the first description of a polyomavirus as an etiological agent of a neoplasm in humans was made only in 2008 with the description of MCPyV, present in approximately 80% of cases of Merkel cell carcinoma (MCC), with the integration of its genome to that of the tumor cells and tumor-specific mutations, and it is considered the etiological agent of this neoplasm since then. MCPyV has also been detected in keratinocyte carcinomas, such as basal cell carcinoma and squamous cell carcinoma of the skin in individuals with and without immunosuppression. Data on the occurrence of oncogenic viruses potentially involved in oncogenesis, which cause persistence and tissue injury, related to the Merkel cell polyomavirus are still scarce, and the hypothesis that the Merkel cell polyomavirus may play a relevant role in the genesis of other cutaneous carcinomas in addition to MCC remains debatable. Therefore, the present study proposes to explore the current knowledge about the presence of MCPyV in keratinocyte carcinomas.
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spelling pubmed-105894872023-10-22 Merkel cell polyomavirus and its etiological relationship with skin tumors() Bellott, Thiago Rubim Luz, Flávio Barbosa Silva, Anna Karoline Fausto da Varella, Rafael Brandão Rochael, Mayra Carrijo Pantaleão, Luciana An Bras Dermatol Continuing Medical Education Viruses have been frequently identified in several human neoplasms, but the etiological role of these viruses in some tumors is still a matter of controversy. Polyomaviruses stand out among the main viruses with oncogenic capacity, specifically the Merkel cell polyomavirus (MCPyV). Recent revisions in the taxonomy of polyomaviruses have divided the Polyomaviridae family into six genera, including 117 species, with a total of 14 currently known human-infecting species. Although the oncogenicity of polyomaviruses has been widely reported in the literature since 1950, the first description of a polyomavirus as an etiological agent of a neoplasm in humans was made only in 2008 with the description of MCPyV, present in approximately 80% of cases of Merkel cell carcinoma (MCC), with the integration of its genome to that of the tumor cells and tumor-specific mutations, and it is considered the etiological agent of this neoplasm since then. MCPyV has also been detected in keratinocyte carcinomas, such as basal cell carcinoma and squamous cell carcinoma of the skin in individuals with and without immunosuppression. Data on the occurrence of oncogenic viruses potentially involved in oncogenesis, which cause persistence and tissue injury, related to the Merkel cell polyomavirus are still scarce, and the hypothesis that the Merkel cell polyomavirus may play a relevant role in the genesis of other cutaneous carcinomas in addition to MCC remains debatable. Therefore, the present study proposes to explore the current knowledge about the presence of MCPyV in keratinocyte carcinomas. Sociedade Brasileira de Dermatologia 2023 2023-07-03 /pmc/articles/PMC10589487/ /pubmed/37407331 http://dx.doi.org/10.1016/j.abd.2023.04.004 Text en © 2023 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Continuing Medical Education
Bellott, Thiago Rubim
Luz, Flávio Barbosa
Silva, Anna Karoline Fausto da
Varella, Rafael Brandão
Rochael, Mayra Carrijo
Pantaleão, Luciana
Merkel cell polyomavirus and its etiological relationship with skin tumors()
title Merkel cell polyomavirus and its etiological relationship with skin tumors()
title_full Merkel cell polyomavirus and its etiological relationship with skin tumors()
title_fullStr Merkel cell polyomavirus and its etiological relationship with skin tumors()
title_full_unstemmed Merkel cell polyomavirus and its etiological relationship with skin tumors()
title_short Merkel cell polyomavirus and its etiological relationship with skin tumors()
title_sort merkel cell polyomavirus and its etiological relationship with skin tumors()
topic Continuing Medical Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589487/
https://www.ncbi.nlm.nih.gov/pubmed/37407331
http://dx.doi.org/10.1016/j.abd.2023.04.004
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