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FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer

The diagnostic efficacy of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) is limited in breast cancer (BC), highlighting the necessity of exploring novel biomarkers to improve for BC diagnosis. Therefore, we assessed the diagnostic value of fat mass and obesity-associated prot...

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Autores principales: Mi, Jintao, Zhang, Hongsheng, Cao, Weiwei, Yuan, Chengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589555/
https://www.ncbi.nlm.nih.gov/pubmed/37861518
http://dx.doi.org/10.1097/MD.0000000000035361
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author Mi, Jintao
Zhang, Hongsheng
Cao, Weiwei
Yuan, Chengliang
author_facet Mi, Jintao
Zhang, Hongsheng
Cao, Weiwei
Yuan, Chengliang
author_sort Mi, Jintao
collection PubMed
description The diagnostic efficacy of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) is limited in breast cancer (BC), highlighting the necessity of exploring novel biomarkers to improve for BC diagnosis. Therefore, we assessed the diagnostic value of fat mass and obesity-associated protein (FTO), phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit β (PIK3CB) as a potential complementary biomarker to CEA and CA153 in breast cancer by measuring serum FTO,PIK3CB levels. FTO, PIK3CB, CEA and CA15-3 levels were measured in 112 BC patients and 64 healthy controls using enzyme-linked immunosorbent assay or electrochemiluminescence immunoassay. Spearman’s rank correlation analysis was conducted to assess the correlation between the levels of the 2 markers. The relationships between FTO, PIK3CB, CEA, CA15-3 and clinical characteristics were evaluated. Receiver operating characteristic curve (ROC) analysis was performed to assess the diagnostic value of FTO, PIK3CB, CEA and CA15-3 of BC. Serum FTO, PIK3CB, CEA and CA15-3 levels were significantly increased in BC. There was no correlation between FTO, PIK3CB and CEA, CA15-3. FTO and PIK3CB demonstrated significant diagnostic performance for breast cancer, with FTO achieving a specificity of 90.63%. The diagnostic performance of 2-four biomarker combinations was significantly superior to individual CEA or CA153, with a combined panel of 4 biomarkers yielding an area under the curve (AUC) of 0.918, sensitivity of 81.25% and specificity of 85.94%. In early-stage breast cancer (I + II), the combination of FTO, PIK3CB, CEA and CA153 yielded an AUC of 0.895, sensitivity of 77.22% and specificity of 85.71%. FTO and PIK3CB can be served as potential biomarkers to complement CEA and CA15-3 for BC diagnosis. Combining FTO, PIK3CB, CEA and CA15-3 improves the diagnostic efficiency of breast cancer.
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spelling pubmed-105895552023-10-22 FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer Mi, Jintao Zhang, Hongsheng Cao, Weiwei Yuan, Chengliang Medicine (Baltimore) 4100 The diagnostic efficacy of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) is limited in breast cancer (BC), highlighting the necessity of exploring novel biomarkers to improve for BC diagnosis. Therefore, we assessed the diagnostic value of fat mass and obesity-associated protein (FTO), phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit β (PIK3CB) as a potential complementary biomarker to CEA and CA153 in breast cancer by measuring serum FTO,PIK3CB levels. FTO, PIK3CB, CEA and CA15-3 levels were measured in 112 BC patients and 64 healthy controls using enzyme-linked immunosorbent assay or electrochemiluminescence immunoassay. Spearman’s rank correlation analysis was conducted to assess the correlation between the levels of the 2 markers. The relationships between FTO, PIK3CB, CEA, CA15-3 and clinical characteristics were evaluated. Receiver operating characteristic curve (ROC) analysis was performed to assess the diagnostic value of FTO, PIK3CB, CEA and CA15-3 of BC. Serum FTO, PIK3CB, CEA and CA15-3 levels were significantly increased in BC. There was no correlation between FTO, PIK3CB and CEA, CA15-3. FTO and PIK3CB demonstrated significant diagnostic performance for breast cancer, with FTO achieving a specificity of 90.63%. The diagnostic performance of 2-four biomarker combinations was significantly superior to individual CEA or CA153, with a combined panel of 4 biomarkers yielding an area under the curve (AUC) of 0.918, sensitivity of 81.25% and specificity of 85.94%. In early-stage breast cancer (I + II), the combination of FTO, PIK3CB, CEA and CA153 yielded an AUC of 0.895, sensitivity of 77.22% and specificity of 85.71%. FTO and PIK3CB can be served as potential biomarkers to complement CEA and CA15-3 for BC diagnosis. Combining FTO, PIK3CB, CEA and CA15-3 improves the diagnostic efficiency of breast cancer. Lippincott Williams & Wilkins 2023-10-20 /pmc/articles/PMC10589555/ /pubmed/37861518 http://dx.doi.org/10.1097/MD.0000000000035361 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4100
Mi, Jintao
Zhang, Hongsheng
Cao, Weiwei
Yuan, Chengliang
FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
title FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
title_full FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
title_fullStr FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
title_full_unstemmed FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
title_short FTO, PIK3CB serve as potential markers to complement CEA and CA15-3 for the diagnosis of breast cancer
title_sort fto, pik3cb serve as potential markers to complement cea and ca15-3 for the diagnosis of breast cancer
topic 4100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589555/
https://www.ncbi.nlm.nih.gov/pubmed/37861518
http://dx.doi.org/10.1097/MD.0000000000035361
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