Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

Genome-wide association studies (GWASs) have successfully identified 145 genomic regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to discern causal variants. We performed a massively parallel reporter assay (MPRA) on 5,173 fine-mapped schizophrenia GWAS...

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Detalles Bibliográficos
Autores principales: McAfee, Jessica C., Lee, Sool, Lee, Jiseok, Bell, Jessica L., Krupa, Oleh, Davis, Jessica, Insigne, Kimberly, Bond, Marielle L., Zhao, Nanxiang, Boyle, Alan P., Phanstiel, Douglas H., Love, Michael I., Stein, Jason L., Ruzicka, W. Brad, Davila-Velderrain, Jose, Kosuri, Sriram, Won, Hyejung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589626/
https://www.ncbi.nlm.nih.gov/pubmed/37868037
http://dx.doi.org/10.1016/j.xgen.2023.100404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589626/
https://www.ncbi.nlm.nih.gov/pubmed/37868037
http://dx.doi.org/10.1016/j.xgen.2023.100404

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