Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations

Transcriptome prediction models built with data from European-descent individuals are less accurate when applied to different populations because of differences in linkage disequilibrium patterns and allele frequencies. We hypothesized that methods that leverage shared regulatory effects across diff...

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Detalles Bibliográficos
Autores principales: Araujo, Daniel S., Nguyen, Chris, Hu, Xiaowei, Mikhaylova, Anna V., Gignoux, Chris, Ardlie, Kristin, Taylor, Kent D., Durda, Peter, Liu, Yongmei, Papanicolaou, George, Cho, Michael H., Rich, Stephen S., Rotter, Jerome I., Im, Hae Kyung, Manichaikul, Ani, Wheeler, Heather E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589725/
https://www.ncbi.nlm.nih.gov/pubmed/37869564
http://dx.doi.org/10.1016/j.xhgg.2023.100216

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