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Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications

Microneedles (MNs) is an emerging technology that employs needles ranging from 10 to 1000 μm in height, as a minimally invasive technique for various procedures such as therapeutics, disease monitoring and diagnostics. The commonly used method of fabrication, micromolding, has the advantage of scala...

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Autores principales: Loh, Jia Min, Lim, Yun Jie Larissa, Tay, Jin Ting, Cheng, Hui Mei, Tey, Hong Liang, Liang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589728/
https://www.ncbi.nlm.nih.gov/pubmed/37869723
http://dx.doi.org/10.1016/j.bioactmat.2023.09.022
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author Loh, Jia Min
Lim, Yun Jie Larissa
Tay, Jin Ting
Cheng, Hui Mei
Tey, Hong Liang
Liang, Kun
author_facet Loh, Jia Min
Lim, Yun Jie Larissa
Tay, Jin Ting
Cheng, Hui Mei
Tey, Hong Liang
Liang, Kun
author_sort Loh, Jia Min
collection PubMed
description Microneedles (MNs) is an emerging technology that employs needles ranging from 10 to 1000 μm in height, as a minimally invasive technique for various procedures such as therapeutics, disease monitoring and diagnostics. The commonly used method of fabrication, micromolding, has the advantage of scalability, however, micromolding is unable to achieve rapid customizability in dimensions, geometries and architectures, which are the pivotal factors determining the functionality and efficacy of the MNs. 3D printing offers a promising alternative by enabling MN fabrication with high dimensional accuracy required for precise applications, leading to improved performance. Furthermore, enabled by its customizability and one-step process, there is propitious potential for growth for 3D-printed MNs especially in the field of personalized and on-demand medical devices. This review provides an overview of considerations for the key parameters in designing MNs, an introduction on the various 3D-printing techniques for fabricating this new generation of MNs, as well as highlighting the advancements in biomedical applications facilitated by 3D-printed MNs. Lastly, we offer some insights into the future prospects of 3D-printed MNs, specifically its progress towards translation and entry into market.
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spelling pubmed-105897282023-10-22 Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications Loh, Jia Min Lim, Yun Jie Larissa Tay, Jin Ting Cheng, Hui Mei Tey, Hong Liang Liang, Kun Bioact Mater Review Article Microneedles (MNs) is an emerging technology that employs needles ranging from 10 to 1000 μm in height, as a minimally invasive technique for various procedures such as therapeutics, disease monitoring and diagnostics. The commonly used method of fabrication, micromolding, has the advantage of scalability, however, micromolding is unable to achieve rapid customizability in dimensions, geometries and architectures, which are the pivotal factors determining the functionality and efficacy of the MNs. 3D printing offers a promising alternative by enabling MN fabrication with high dimensional accuracy required for precise applications, leading to improved performance. Furthermore, enabled by its customizability and one-step process, there is propitious potential for growth for 3D-printed MNs especially in the field of personalized and on-demand medical devices. This review provides an overview of considerations for the key parameters in designing MNs, an introduction on the various 3D-printing techniques for fabricating this new generation of MNs, as well as highlighting the advancements in biomedical applications facilitated by 3D-printed MNs. Lastly, we offer some insights into the future prospects of 3D-printed MNs, specifically its progress towards translation and entry into market. KeAi Publishing 2023-10-12 /pmc/articles/PMC10589728/ /pubmed/37869723 http://dx.doi.org/10.1016/j.bioactmat.2023.09.022 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Loh, Jia Min
Lim, Yun Jie Larissa
Tay, Jin Ting
Cheng, Hui Mei
Tey, Hong Liang
Liang, Kun
Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
title Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
title_full Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
title_fullStr Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
title_full_unstemmed Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
title_short Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications
title_sort design and fabrication of customizable microneedles enabled by 3d printing for biomedical applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589728/
https://www.ncbi.nlm.nih.gov/pubmed/37869723
http://dx.doi.org/10.1016/j.bioactmat.2023.09.022
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