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Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy
BACKGROUND AND PURPOSE: Due to advances in oncology, a growing proportion of patients is treated with repetitive courses of radiotherapy. The aim of this study is to analyze whether radiotherapy maintains its safety and efficacy profile in patients treated with multiple repeat courses of irradiation...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589769/ https://www.ncbi.nlm.nih.gov/pubmed/37867613 http://dx.doi.org/10.1016/j.ctro.2023.100687 |
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author | Ahmadsei, Maiwand Christ, Sebastian M. Kroese, Tiuri E. Kühnis, Anja Willmann, Jonas Balermpas, Panagiotis Andratschke, Nicolaus Tanadini-Lang, Stephanie Guckenberger, Matthias |
author_facet | Ahmadsei, Maiwand Christ, Sebastian M. Kroese, Tiuri E. Kühnis, Anja Willmann, Jonas Balermpas, Panagiotis Andratschke, Nicolaus Tanadini-Lang, Stephanie Guckenberger, Matthias |
author_sort | Ahmadsei, Maiwand |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Due to advances in oncology, a growing proportion of patients is treated with repetitive courses of radiotherapy. The aim of this study is to analyze whether radiotherapy maintains its safety and efficacy profile in patients treated with multiple repeat courses of irradiation. MATERIAL AND METHODS: All patients treated between 2011 and 2019 at our institution were screened for a minimum of five repeat irradiation courses, to analyze treatment characteristics, survival, safety and efficacy. The type of re-irradiation was classified according to ESTRO-EORTC consensus guidelines. RESULTS: A total of n = 112 patients receiving n = 660 radiotherapy courses were included in this retrospective cohort study. The most frequent primary tumors were lung cancer in 41.9 % (n = 47) and malignant melanoma in 8.9 % (n = 10). The most frequent re-irradiation types were repeat irradiation and Type 2 re-irradiation in 309 (46.8 %) and 113 (17.1 %) cases, respectively. Median survival after the first course of radiotherapy was 3.6 (0.3–13.4) years. Response to radiotherapy was observed in 548 (83.0 %) cases and CTCAE toxicity grade ≥ 3 was observed in 21 (3.2 %) cases. An increasing number of RT courses (HR: 1.30, p=<0.0001), Type 1 re-irradiation (HR 3.50, p = 0.008) and KPS ≤ 80 % (HR: 2.02, p = 0.002) were associated with significantly worse treatment responses. Toxicity rates remained stable with increasing numbers of RT courses. CONCLUSION: Multiple courses of repeat radiotherapy maintain a favorable therapeutic ratio of high response combined with reasonable safety profile. |
format | Online Article Text |
id | pubmed-10589769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105897692023-10-22 Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy Ahmadsei, Maiwand Christ, Sebastian M. Kroese, Tiuri E. Kühnis, Anja Willmann, Jonas Balermpas, Panagiotis Andratschke, Nicolaus Tanadini-Lang, Stephanie Guckenberger, Matthias Clin Transl Radiat Oncol Original Research Article BACKGROUND AND PURPOSE: Due to advances in oncology, a growing proportion of patients is treated with repetitive courses of radiotherapy. The aim of this study is to analyze whether radiotherapy maintains its safety and efficacy profile in patients treated with multiple repeat courses of irradiation. MATERIAL AND METHODS: All patients treated between 2011 and 2019 at our institution were screened for a minimum of five repeat irradiation courses, to analyze treatment characteristics, survival, safety and efficacy. The type of re-irradiation was classified according to ESTRO-EORTC consensus guidelines. RESULTS: A total of n = 112 patients receiving n = 660 radiotherapy courses were included in this retrospective cohort study. The most frequent primary tumors were lung cancer in 41.9 % (n = 47) and malignant melanoma in 8.9 % (n = 10). The most frequent re-irradiation types were repeat irradiation and Type 2 re-irradiation in 309 (46.8 %) and 113 (17.1 %) cases, respectively. Median survival after the first course of radiotherapy was 3.6 (0.3–13.4) years. Response to radiotherapy was observed in 548 (83.0 %) cases and CTCAE toxicity grade ≥ 3 was observed in 21 (3.2 %) cases. An increasing number of RT courses (HR: 1.30, p=<0.0001), Type 1 re-irradiation (HR 3.50, p = 0.008) and KPS ≤ 80 % (HR: 2.02, p = 0.002) were associated with significantly worse treatment responses. Toxicity rates remained stable with increasing numbers of RT courses. CONCLUSION: Multiple courses of repeat radiotherapy maintain a favorable therapeutic ratio of high response combined with reasonable safety profile. Elsevier 2023-10-02 /pmc/articles/PMC10589769/ /pubmed/37867613 http://dx.doi.org/10.1016/j.ctro.2023.100687 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Article Ahmadsei, Maiwand Christ, Sebastian M. Kroese, Tiuri E. Kühnis, Anja Willmann, Jonas Balermpas, Panagiotis Andratschke, Nicolaus Tanadini-Lang, Stephanie Guckenberger, Matthias Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
title | Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
title_full | Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
title_fullStr | Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
title_full_unstemmed | Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
title_short | Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
title_sort | efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589769/ https://www.ncbi.nlm.nih.gov/pubmed/37867613 http://dx.doi.org/10.1016/j.ctro.2023.100687 |
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