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Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
BACKGROUND: Following the “hygiene hypothesis”, the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sib...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590346/ https://www.ncbi.nlm.nih.gov/pubmed/36997765 http://dx.doi.org/10.1007/s12519-023-00706-w |
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author | Lisik, Daniil Ermis, Saliha Selin Özuygur Ioannidou, Athina Milani, Gregorio Paolo Nyassi, Sungkutu Spolidoro, Giulia Carla Immacolata Kankaanranta, Hannu Goksör, Emma Wennergren, Göran Nwaru, Bright Ibeabughichi |
author_facet | Lisik, Daniil Ermis, Saliha Selin Özuygur Ioannidou, Athina Milani, Gregorio Paolo Nyassi, Sungkutu Spolidoro, Giulia Carla Immacolata Kankaanranta, Hannu Goksör, Emma Wennergren, Göran Nwaru, Bright Ibeabughichi |
author_sort | Lisik, Daniil |
collection | PubMed |
description | BACKGROUND: Following the “hygiene hypothesis”, the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sibship size and birth order with risk of asthma and wheezing. METHODS: Fifteen databases were searched to identify eligible studies. Study selection and data extraction were performed independently by pairs of reviewers. Meta-analysis with robust variance estimation (RVE) was used to produce pooled risk ratio (RR) effect estimates from comparable numerical data. RESULTS: From 17,466 identified records, 158 reports of 134 studies (> 3 million subjects) were included. Any wheezing in the last ≤ 1.5 years occurred more frequently in infants with ≥ 1 sibling [pooled RR 1.10, 95% confidence interval (CI) 1.02–1.19] and ≥ 1 older sibling (pooled RR 1.16, 95% CI 1.04–1.29). The pooled effect sizes for asthma were overall statistically nonsignificant, although having ≥ 1 older sibling was marginally protective for subjects aged ≥ 6 years (pooled RR 0.93, 95% CI 0.88–0.99). The effect estimates weakened in studies published after 2000 compared with earlier studies. CONCLUSIONS: Being second-born or later and having at least one sibling is associated with a slightly increased risk of temporary wheezing in infancy. In contrast, being second-born or later is associated with marginal protection against asthma. These associations appear to have weakened since the turn of the millennium, possibly due to lifestyle changes and socioeconomic development. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12519-023-00706-w. |
format | Online Article Text |
id | pubmed-10590346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-105903462023-10-23 Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis Lisik, Daniil Ermis, Saliha Selin Özuygur Ioannidou, Athina Milani, Gregorio Paolo Nyassi, Sungkutu Spolidoro, Giulia Carla Immacolata Kankaanranta, Hannu Goksör, Emma Wennergren, Göran Nwaru, Bright Ibeabughichi World J Pediatr Meta-Analysis BACKGROUND: Following the “hygiene hypothesis”, the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sibship size and birth order with risk of asthma and wheezing. METHODS: Fifteen databases were searched to identify eligible studies. Study selection and data extraction were performed independently by pairs of reviewers. Meta-analysis with robust variance estimation (RVE) was used to produce pooled risk ratio (RR) effect estimates from comparable numerical data. RESULTS: From 17,466 identified records, 158 reports of 134 studies (> 3 million subjects) were included. Any wheezing in the last ≤ 1.5 years occurred more frequently in infants with ≥ 1 sibling [pooled RR 1.10, 95% confidence interval (CI) 1.02–1.19] and ≥ 1 older sibling (pooled RR 1.16, 95% CI 1.04–1.29). The pooled effect sizes for asthma were overall statistically nonsignificant, although having ≥ 1 older sibling was marginally protective for subjects aged ≥ 6 years (pooled RR 0.93, 95% CI 0.88–0.99). The effect estimates weakened in studies published after 2000 compared with earlier studies. CONCLUSIONS: Being second-born or later and having at least one sibling is associated with a slightly increased risk of temporary wheezing in infancy. In contrast, being second-born or later is associated with marginal protection against asthma. These associations appear to have weakened since the turn of the millennium, possibly due to lifestyle changes and socioeconomic development. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12519-023-00706-w. Springer Nature Singapore 2023-03-30 2023 /pmc/articles/PMC10590346/ /pubmed/36997765 http://dx.doi.org/10.1007/s12519-023-00706-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Meta-Analysis Lisik, Daniil Ermis, Saliha Selin Özuygur Ioannidou, Athina Milani, Gregorio Paolo Nyassi, Sungkutu Spolidoro, Giulia Carla Immacolata Kankaanranta, Hannu Goksör, Emma Wennergren, Göran Nwaru, Bright Ibeabughichi Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis |
title | Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis |
title_full | Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis |
title_fullStr | Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis |
title_full_unstemmed | Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis |
title_short | Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis |
title_sort | is sibship composition a risk factor for childhood asthma? systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590346/ https://www.ncbi.nlm.nih.gov/pubmed/36997765 http://dx.doi.org/10.1007/s12519-023-00706-w |
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