Cargando…

Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis

BACKGROUND: Following the “hygiene hypothesis”, the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sib...

Descripción completa

Detalles Bibliográficos
Autores principales: Lisik, Daniil, Ermis, Saliha Selin Özuygur, Ioannidou, Athina, Milani, Gregorio Paolo, Nyassi, Sungkutu, Spolidoro, Giulia Carla Immacolata, Kankaanranta, Hannu, Goksör, Emma, Wennergren, Göran, Nwaru, Bright Ibeabughichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590346/
https://www.ncbi.nlm.nih.gov/pubmed/36997765
http://dx.doi.org/10.1007/s12519-023-00706-w
_version_ 1785123971207790592
author Lisik, Daniil
Ermis, Saliha Selin Özuygur
Ioannidou, Athina
Milani, Gregorio Paolo
Nyassi, Sungkutu
Spolidoro, Giulia Carla Immacolata
Kankaanranta, Hannu
Goksör, Emma
Wennergren, Göran
Nwaru, Bright Ibeabughichi
author_facet Lisik, Daniil
Ermis, Saliha Selin Özuygur
Ioannidou, Athina
Milani, Gregorio Paolo
Nyassi, Sungkutu
Spolidoro, Giulia Carla Immacolata
Kankaanranta, Hannu
Goksör, Emma
Wennergren, Göran
Nwaru, Bright Ibeabughichi
author_sort Lisik, Daniil
collection PubMed
description BACKGROUND: Following the “hygiene hypothesis”, the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sibship size and birth order with risk of asthma and wheezing. METHODS: Fifteen databases were searched to identify eligible studies. Study selection and data extraction were performed independently by pairs of reviewers. Meta-analysis with robust variance estimation (RVE) was used to produce pooled risk ratio (RR) effect estimates from comparable numerical data. RESULTS: From 17,466 identified records, 158 reports of 134 studies (> 3 million subjects) were included. Any wheezing in the last ≤ 1.5 years occurred more frequently in infants with ≥ 1 sibling [pooled RR 1.10, 95% confidence interval (CI) 1.02–1.19] and ≥ 1 older sibling (pooled RR 1.16, 95% CI 1.04–1.29). The pooled effect sizes for asthma were overall statistically nonsignificant, although having ≥ 1 older sibling was marginally protective for subjects aged ≥ 6 years (pooled RR 0.93, 95% CI 0.88–0.99). The effect estimates weakened in studies published after 2000 compared with earlier studies. CONCLUSIONS: Being second-born or later and having at least one sibling is associated with a slightly increased risk of temporary wheezing in infancy. In contrast, being second-born or later is associated with marginal protection against asthma. These associations appear to have weakened since the turn of the millennium, possibly due to lifestyle changes and socioeconomic development. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12519-023-00706-w.
format Online
Article
Text
id pubmed-10590346
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Nature Singapore
record_format MEDLINE/PubMed
spelling pubmed-105903462023-10-23 Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis Lisik, Daniil Ermis, Saliha Selin Özuygur Ioannidou, Athina Milani, Gregorio Paolo Nyassi, Sungkutu Spolidoro, Giulia Carla Immacolata Kankaanranta, Hannu Goksör, Emma Wennergren, Göran Nwaru, Bright Ibeabughichi World J Pediatr Meta-Analysis BACKGROUND: Following the “hygiene hypothesis”, the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sibship size and birth order with risk of asthma and wheezing. METHODS: Fifteen databases were searched to identify eligible studies. Study selection and data extraction were performed independently by pairs of reviewers. Meta-analysis with robust variance estimation (RVE) was used to produce pooled risk ratio (RR) effect estimates from comparable numerical data. RESULTS: From 17,466 identified records, 158 reports of 134 studies (> 3 million subjects) were included. Any wheezing in the last ≤ 1.5 years occurred more frequently in infants with ≥ 1 sibling [pooled RR 1.10, 95% confidence interval (CI) 1.02–1.19] and ≥ 1 older sibling (pooled RR 1.16, 95% CI 1.04–1.29). The pooled effect sizes for asthma were overall statistically nonsignificant, although having ≥ 1 older sibling was marginally protective for subjects aged ≥ 6 years (pooled RR 0.93, 95% CI 0.88–0.99). The effect estimates weakened in studies published after 2000 compared with earlier studies. CONCLUSIONS: Being second-born or later and having at least one sibling is associated with a slightly increased risk of temporary wheezing in infancy. In contrast, being second-born or later is associated with marginal protection against asthma. These associations appear to have weakened since the turn of the millennium, possibly due to lifestyle changes and socioeconomic development. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12519-023-00706-w. Springer Nature Singapore 2023-03-30 2023 /pmc/articles/PMC10590346/ /pubmed/36997765 http://dx.doi.org/10.1007/s12519-023-00706-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Meta-Analysis
Lisik, Daniil
Ermis, Saliha Selin Özuygur
Ioannidou, Athina
Milani, Gregorio Paolo
Nyassi, Sungkutu
Spolidoro, Giulia Carla Immacolata
Kankaanranta, Hannu
Goksör, Emma
Wennergren, Göran
Nwaru, Bright Ibeabughichi
Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
title Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
title_full Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
title_fullStr Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
title_full_unstemmed Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
title_short Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis
title_sort is sibship composition a risk factor for childhood asthma? systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590346/
https://www.ncbi.nlm.nih.gov/pubmed/36997765
http://dx.doi.org/10.1007/s12519-023-00706-w
work_keys_str_mv AT lisikdaniil issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT ermissalihaselinozuygur issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT ioannidouathina issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT milanigregoriopaolo issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT nyassisungkutu issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT spolidorogiuliacarlaimmacolata issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT kankaanrantahannu issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT goksoremma issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT wennergrengoran issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis
AT nwarubrightibeabughichi issibshipcompositionariskfactorforchildhoodasthmasystematicreviewandmetaanalysis