Cargando…

Expanding causal genes for Parkinson’s disease via multi-omics analysis

Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are available. To find potential causal genes and explore genetically supported drug targets fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Xiao-Jing, Su, Wei-Ming, Dou, Meng, Jiang, Zheng, Duan, Qing-Qing, Yin, Kang-Fu, Cao, Bei, Wang, Yi, Li, Guo-Bo, Chen, Yong-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590374/ https://www.ncbi.nlm.nih.gov/pubmed/37865667 http://dx.doi.org/10.1038/s41531-023-00591-0

Ejemplares similares

Protective effect of antihypertensive drugs on the risk of Parkinson’s disease lacks causal evidence from mendelian randomization
por: Jiang, Zheng, et al.
Publicado: (2023)

Advancing Physiology with Expanded Multi-Omics
por: Liang, Mingyu, et al.
Publicado: (2022)

From ‘Omics to Multi-omics Technologies: the Discovery of Novel Causal Mediators
por: Mohammadi-Shemirani, Pedrum, et al.
Publicado: (2023)

Multi-omics Data Integration for Identifying Osteoporosis Biomarkers and Their Biological Interaction and Causal Mechanisms
por: Qiu, Chuan, et al.
Publicado: (2020)

Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer’s disease
por: Su, Wei-Ming, et al.
Publicado: (2023)

Identifying Multi-Omics Causers and Causal Pathways for Complex Traits
por: Qin, Huaizhen, et al.
Publicado: (2019)

Causal modeling in a multi-omic setting: insights from GAW20
por: Auerbach, Jonathan, et al.
Publicado: (2018)

Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses
por: Dugourd, Aurelien, et al.
Publicado: (2021)

From classical mendelian randomization to causal networks for systematic integration of multi-omics
por: Yazdani, Azam, et al.
Publicado: (2022)

Systems Biology Approaches for Host–Fungal Interactions: An Expanding Multi-Omics Frontier
por: Culibrk, Luka, et al.
Publicado: (2016)

Integrated multi-omics analysis of genomics, epigenomics, and transcriptomics in ovarian carcinoma
por: Zheng, Mingjun, et al.
Publicado: (2019)

Aristotle: stratified causal discovery for omics data
por: Mansouri, Mehrdad, et al.
Publicado: (2022)

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19
por: Hernández Cordero, Ana I., et al.
Publicado: (2021)

Federated Learning for multi-omics: a performance evaluation in Parkinson’s disease
por: Danek, Benjamin, et al.
Publicado: (2023)

Machine learning for multi-omics data integration in cancer
por: Cai, Zhaoxiang, et al.
Publicado: (2022)

Multi-omics protein-coding units as massively parallel Bayesian networks: Empirical validation of causality structure
por: Zenere, Alberto, et al.
Publicado: (2022)

Essential Regression: A generalizable framework for inferring causal latent factors from multi-omic datasets
por: Bing, Xin, et al.
Publicado: (2022)

MRGCN: cancer subtyping with multi-reconstruction graph convolutional network using full and partial multi-omics dataset
por: Yang, Bo, et al.
Publicado: (2023)

Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data
por: Gu, Xiaojing, et al.
Publicado: (2022)

The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
por: Yang, Guang, et al.
Publicado: (2022)

Multi-omics in Crohn's disease: New insights from inside
por: Mu, Chenlu, et al.
Publicado: (2023)

Identification of biomarkers for early diagnosis of Parkinson's disease by multi-omics joint analysis
por: Hu, Chaokai, et al.
Publicado: (2020)

CLCLSA: Cross-omics Linked embedding with Contrastive Learning and Self Attention for multi-omics integration with incomplete multi-omics data
por: Zhao, Chen, et al.
Publicado: (2023)

CLCLSA: Cross-omics Linked embedding with Contrastive Learning and Self Attention for multi-omics integration with incomplete multi-omics data
por: Zhao, Chen, et al.
Publicado: (2023)

An integrative U method for joint analysis of multi-level omic data
por: Geng, Pei, et al.
Publicado: (2019)

Revealing the Specific Regulations of Brassinolide on Tomato Fruit Chilling Injury by Integrated Multi-Omics
por: Bai, Chunmei, et al.
Publicado: (2021)

Integrative analysis of multi-omics data to detect the underlying molecular mechanisms for obesity in vivo in humans
por: Zhang, Qiang, et al.
Publicado: (2022)

Omics and Multi-Omics in IBD: No Integration, No Breakthroughs
por: Fiocchi, Claudio
Publicado: (2023)

A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research
por: Vlachavas, Efstathios Iason, et al.
Publicado: (2021)

Viral Causality of Human Cancer and Potential Roles of Human Endogenous Retroviruses in the Multi-Omics Era: An Evolutionary Epidemiology Review
por: Kitsou, Konstantina, et al.
Publicado: (2021)

NGMA-3. Use of multi-omics data to initialize and validate a causal model of glioblastoma stem cell signaling
por: Holtzapple, Emilee, et al.
Publicado: (2021)

Investigation on acquired palbociclib resistance by LC-MS based multi-omics analysis
por: Xue, Zhichao, et al.
Publicado: (2023)

Identification of Parkinson’s Disease-Causing Genes via Omics Data
por: Cui, Xinran, et al.
Publicado: (2021)

A Review of Integrative Imputation for Multi-Omics Datasets
por: Song, Meng, et al.
Publicado: (2020)

Building Personalized Cancer Therapeutics through Multi-Omics Assays and Bacteriophage-Eukaryotic Cell Interactions
por: Wang, Qing
Publicado: (2021)

Multi-Omics Analysis Reveals Novel Subtypes and Driver Genes in Glioblastoma
por: Yuan, Yang, et al.
Publicado: (2020)

Integrated Multi-Omics Perspective to Strengthen the Understanding of Salt Tolerance in Rice
por: Dai, Liping, et al.
Publicado: (2022)

Multi-Omics Data Integration Analysis of an Immune-Related Gene Signature in LGG Patients With Epilepsy
por: Cheng, Quan, et al.
Publicado: (2021)

MONET: Multi-omic module discovery by omic selection
por: Rappoport, Nimrod, et al.
Publicado: (2020)

From meta-omics to causality: experimental models for human microbiome research
por: Fritz, Joëlle V, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_on7bmq2id9mas0rdpj2ubbe43o