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Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy
A true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO(2), formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To rend...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590403/ https://www.ncbi.nlm.nih.gov/pubmed/37865689 http://dx.doi.org/10.1038/s41467-023-42166-w |
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author | Orsi, Enrico Nikel, Pablo Ivan Nielsen, Lars Keld Donati, Stefano |
author_facet | Orsi, Enrico Nikel, Pablo Ivan Nielsen, Lars Keld Donati, Stefano |
author_sort | Orsi, Enrico |
collection | PubMed |
description | A true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO(2), formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To render C1-based biomanufacturing cost-competitive, we must adapt microbial metabolism to perform chemical conversions at high rates and yields. To this end, the biotechnology community has undertaken two (seemingly opposing) paths: optimizing natural C1-trophic microorganisms versus engineering synthetic C1-assimilation de novo in model microorganisms. Here, we pose how these approaches can instead create synergies for strengthening the competitiveness of C1-based biomanufacturing as a whole. |
format | Online Article Text |
id | pubmed-10590403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105904032023-10-23 Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy Orsi, Enrico Nikel, Pablo Ivan Nielsen, Lars Keld Donati, Stefano Nat Commun Perspective A true circular carbon economy must upgrade waste greenhouse gases. C1-based biomanufacturing is an attractive solution, in which one carbon (C1) molecules (e.g. CO(2), formate, methanol, etc.) are converted by microbial cell factories into value-added goods (i.e. food, feed, and chemicals). To render C1-based biomanufacturing cost-competitive, we must adapt microbial metabolism to perform chemical conversions at high rates and yields. To this end, the biotechnology community has undertaken two (seemingly opposing) paths: optimizing natural C1-trophic microorganisms versus engineering synthetic C1-assimilation de novo in model microorganisms. Here, we pose how these approaches can instead create synergies for strengthening the competitiveness of C1-based biomanufacturing as a whole. Nature Publishing Group UK 2023-10-21 /pmc/articles/PMC10590403/ /pubmed/37865689 http://dx.doi.org/10.1038/s41467-023-42166-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Perspective Orsi, Enrico Nikel, Pablo Ivan Nielsen, Lars Keld Donati, Stefano Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy |
title | Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy |
title_full | Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy |
title_fullStr | Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy |
title_full_unstemmed | Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy |
title_short | Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy |
title_sort | synergistic investigation of natural and synthetic c1-trophic microorganisms to foster a circular carbon economy |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590403/ https://www.ncbi.nlm.nih.gov/pubmed/37865689 http://dx.doi.org/10.1038/s41467-023-42166-w |
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