Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease

Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein that is predominantly expressed by microglia in the brain. The proteolytic shedding of TREM2 results in the release of soluble TREM2 (sTREM2), which is increased in the cerebrospinal fluid of patients with Alzheimer’...

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Detalles Bibliográficos
Autores principales: Zhang, Xingyu, Tang, Li, Yang, Jiaolong, Meng, Lanxia, Chen, Jiehui, Zhou, Lingyan, Wang, Jiangyu, Xiong, Min, Zhang, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590452/
https://www.ncbi.nlm.nih.gov/pubmed/37865646
http://dx.doi.org/10.1038/s41467-023-42505-x

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