A comprehensive model for tRNA methylation modification studies

The molecular mechanism of N(7)‐methylguanosine (m(7)G)‐tRNA modification mediated by the methyltransferase like 1‐WD repeat domain 4 (METTL1–WDR4). Route A indicated that with WDR4 as the scaffold, METTL1 catalyzed G46 methylation modification after binding of the tRNA variable loop via its αC and...

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Detalles Bibliográficos
Autores principales: Weng, Qi, Zhang, Feng, Zheng, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590456/
https://www.ncbi.nlm.nih.gov/pubmed/37873513
http://dx.doi.org/10.1002/mco2.402
Descripción
Sumario:The molecular mechanism of N(7)‐methylguanosine (m(7)G)‐tRNA modification mediated by the methyltransferase like 1‐WD repeat domain 4 (METTL1–WDR4). Route A indicated that with WDR4 as the scaffold, METTL1 catalyzed G46 methylation modification after binding of the tRNA variable loop via its αC and α6 helices, as reported by Richard I. Gregory's group. Route B showed the METTL1–WDR4‐mediated tRNA methylation modification model and the effect of binding of the S‐adenosylmethionine on the N‐terminus of METTL1, as reported by Yunsun Nam's group. [Image: see text]

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