A comprehensive model for tRNA methylation modification studies

The molecular mechanism of N(7)‐methylguanosine (m(7)G)‐tRNA modification mediated by the methyltransferase like 1‐WD repeat domain 4 (METTL1–WDR4). Route A indicated that with WDR4 as the scaffold, METTL1 catalyzed G46 methylation modification after binding of the tRNA variable loop via its αC and...

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Detalles Bibliográficos
Autores principales: Weng, Qi, Zhang, Feng, Zheng, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590456/
https://www.ncbi.nlm.nih.gov/pubmed/37873513
http://dx.doi.org/10.1002/mco2.402
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author Weng, Qi
Zhang, Feng
Zheng, Quan
author_facet Weng, Qi
Zhang, Feng
Zheng, Quan
author_sort Weng, Qi
collection PubMed
description The molecular mechanism of N(7)‐methylguanosine (m(7)G)‐tRNA modification mediated by the methyltransferase like 1‐WD repeat domain 4 (METTL1–WDR4). Route A indicated that with WDR4 as the scaffold, METTL1 catalyzed G46 methylation modification after binding of the tRNA variable loop via its αC and α6 helices, as reported by Richard I. Gregory's group. Route B showed the METTL1–WDR4‐mediated tRNA methylation modification model and the effect of binding of the S‐adenosylmethionine on the N‐terminus of METTL1, as reported by Yunsun Nam's group. [Image: see text]
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spelling pubmed-105904562023-10-23 A comprehensive model for tRNA methylation modification studies Weng, Qi Zhang, Feng Zheng, Quan MedComm (2020) Highlights The molecular mechanism of N(7)‐methylguanosine (m(7)G)‐tRNA modification mediated by the methyltransferase like 1‐WD repeat domain 4 (METTL1–WDR4). Route A indicated that with WDR4 as the scaffold, METTL1 catalyzed G46 methylation modification after binding of the tRNA variable loop via its αC and α6 helices, as reported by Richard I. Gregory's group. Route B showed the METTL1–WDR4‐mediated tRNA methylation modification model and the effect of binding of the S‐adenosylmethionine on the N‐terminus of METTL1, as reported by Yunsun Nam's group. [Image: see text] John Wiley and Sons Inc. 2023-10-21 /pmc/articles/PMC10590456/ /pubmed/37873513 http://dx.doi.org/10.1002/mco2.402 Text en © 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Highlights
Weng, Qi
Zhang, Feng
Zheng, Quan
A comprehensive model for tRNA methylation modification studies
title A comprehensive model for tRNA methylation modification studies
title_full A comprehensive model for tRNA methylation modification studies
title_fullStr A comprehensive model for tRNA methylation modification studies
title_full_unstemmed A comprehensive model for tRNA methylation modification studies
title_short A comprehensive model for tRNA methylation modification studies
title_sort comprehensive model for trna methylation modification studies
topic Highlights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590456/
https://www.ncbi.nlm.nih.gov/pubmed/37873513
http://dx.doi.org/10.1002/mco2.402
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