Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options

Aplastic anemia (AA) is a hematopoietic stem cell (HSC) disorder characterized by the loss of HSCs, bone marrow failure, and peripheral pancytopenia. AA is classified as very severe (VSAA), severe (SAA), or non-severe (NSAA) based on the severity criteria. This classification system has implications...

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Detalles Bibliográficos
Autores principales: Alobaidi, Ahmed, Albadry, Ahmed, Murray, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590479/
https://www.ncbi.nlm.nih.gov/pubmed/37872935
http://dx.doi.org/10.7759/cureus.45750
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author Alobaidi, Ahmed
Albadry, Ahmed
Murray, Anne
author_facet Alobaidi, Ahmed
Albadry, Ahmed
Murray, Anne
author_sort Alobaidi, Ahmed
collection PubMed
description Aplastic anemia (AA) is a hematopoietic stem cell (HSC) disorder characterized by the loss of HSCs, bone marrow failure, and peripheral pancytopenia. AA is classified as very severe (VSAA), severe (SAA), or non-severe (NSAA) based on the severity criteria. This classification system has implications for the prognosis and treatment options offered to patients. The prognosis of AA has improved over the past several decades with the advancements in supportive care, HSC transplant (HCT), and immunosuppressive therapy (IST). In this report, we present the case of a 26-year-old male diagnosed with VSAA after presenting with severe neutropenia and fever. The patient ultimately underwent HSC transplantation.
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spelling pubmed-105904792023-10-23 Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options Alobaidi, Ahmed Albadry, Ahmed Murray, Anne Cureus Internal Medicine Aplastic anemia (AA) is a hematopoietic stem cell (HSC) disorder characterized by the loss of HSCs, bone marrow failure, and peripheral pancytopenia. AA is classified as very severe (VSAA), severe (SAA), or non-severe (NSAA) based on the severity criteria. This classification system has implications for the prognosis and treatment options offered to patients. The prognosis of AA has improved over the past several decades with the advancements in supportive care, HSC transplant (HCT), and immunosuppressive therapy (IST). In this report, we present the case of a 26-year-old male diagnosed with VSAA after presenting with severe neutropenia and fever. The patient ultimately underwent HSC transplantation. Cureus 2023-09-22 /pmc/articles/PMC10590479/ /pubmed/37872935 http://dx.doi.org/10.7759/cureus.45750 Text en Copyright © 2023, Alobaidi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Alobaidi, Ahmed
Albadry, Ahmed
Murray, Anne
Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options
title Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options
title_full Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options
title_fullStr Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options
title_full_unstemmed Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options
title_short Very Severe Aplastic Anemia in a 26-Year-Old Male: Implications for Prognosis and Treatment Options
title_sort very severe aplastic anemia in a 26-year-old male: implications for prognosis and treatment options
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590479/
https://www.ncbi.nlm.nih.gov/pubmed/37872935
http://dx.doi.org/10.7759/cureus.45750
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