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Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes
AIMS/HYPOTHESIS: The study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes. METHODS: One hundred sixty children and adolescents aged 6–18, 125 patients with type 1 diabetes, and 35 healthy volunteer...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590527/ https://www.ncbi.nlm.nih.gov/pubmed/37865774 http://dx.doi.org/10.1186/s12933-023-02031-y |
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author | Bogusz-Górna, Klaudia Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Żaba, Ryszard Sumińska, Marta Fichna, Piotr Kędzia, Andrzej |
author_facet | Bogusz-Górna, Klaudia Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Żaba, Ryszard Sumińska, Marta Fichna, Piotr Kędzia, Andrzej |
author_sort | Bogusz-Górna, Klaudia |
collection | PubMed |
description | AIMS/HYPOTHESIS: The study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes. METHODS: One hundred sixty children and adolescents aged 6–18, 125 patients with type 1 diabetes, and 35 healthy volunteers were enrolled in the study. We performed a detailed clinical evaluation, anthropometric measurements, nailfold capillaroscopy, and photoplethysmography. RESULTS: Patients with diabetes had more often abnormal morphology in capillaroscopy (68.60%, p = 0.019), enlarged capillaries (32.6%, p = 0.006), and more often more over five meandering capillaries (20.90%, p = 0.026) compared to healthy controls. Meandering capillaries correlated with higher parameters of nutritional status. In a photoplethysmography, patients with diagnosed neuropathy had a higher percentage of flow disturbance curves (p < 0.001) with a reduced frequency of normal curves (p = 0.050). CONCLUSIONS: Capillaroscopic and photoplethysmographic examinations are non-invasive, painless, fast, and inexpensive. They are devoid of side effects, and there are no limitations in the frequency of their use and repetition. The usefulness of capillaroscopy and photoplethysmography in the study of microcirculation in diabetic patients indicates the vast application possibilities of these methods in clinical practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-02031-y. |
format | Online Article Text |
id | pubmed-10590527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105905272023-10-23 Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes Bogusz-Górna, Klaudia Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Żaba, Ryszard Sumińska, Marta Fichna, Piotr Kędzia, Andrzej Cardiovasc Diabetol Research AIMS/HYPOTHESIS: The study aimed to assess the usefulness of capillaroscopy and photoplethysmography in the search for early vascular anomalies in children with type 1 diabetes. METHODS: One hundred sixty children and adolescents aged 6–18, 125 patients with type 1 diabetes, and 35 healthy volunteers were enrolled in the study. We performed a detailed clinical evaluation, anthropometric measurements, nailfold capillaroscopy, and photoplethysmography. RESULTS: Patients with diabetes had more often abnormal morphology in capillaroscopy (68.60%, p = 0.019), enlarged capillaries (32.6%, p = 0.006), and more often more over five meandering capillaries (20.90%, p = 0.026) compared to healthy controls. Meandering capillaries correlated with higher parameters of nutritional status. In a photoplethysmography, patients with diagnosed neuropathy had a higher percentage of flow disturbance curves (p < 0.001) with a reduced frequency of normal curves (p = 0.050). CONCLUSIONS: Capillaroscopic and photoplethysmographic examinations are non-invasive, painless, fast, and inexpensive. They are devoid of side effects, and there are no limitations in the frequency of their use and repetition. The usefulness of capillaroscopy and photoplethysmography in the study of microcirculation in diabetic patients indicates the vast application possibilities of these methods in clinical practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-02031-y. BioMed Central 2023-10-21 /pmc/articles/PMC10590527/ /pubmed/37865774 http://dx.doi.org/10.1186/s12933-023-02031-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Bogusz-Górna, Klaudia Polańska, Adriana Dańczak-Pazdrowska, Aleksandra Żaba, Ryszard Sumińska, Marta Fichna, Piotr Kędzia, Andrzej Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
title | Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
title_full | Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
title_fullStr | Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
title_full_unstemmed | Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
title_short | Non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
title_sort | non-invasive detection of early microvascular changes in juveniles with type 1 diabetes |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590527/ https://www.ncbi.nlm.nih.gov/pubmed/37865774 http://dx.doi.org/10.1186/s12933-023-02031-y |
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