Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells

Microglia, the primary immune cells of the central nervous system (CNS), are derived from the yolk sac and populate the brain during development. Once microglia migrate to the CNS, they are self-renewing and require CSF1R signaling for their maintenance. Pexidartinib (PLX3397, PLX), a small molecule...

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Detalles Bibliográficos
Autores principales: Okojie, Akhabue K., Uweru, Joseph O., Coburn, Morgan A., Li, Sihan, Cao-Dao, Vivian D., Eyo, Ukpong B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590528/
https://www.ncbi.nlm.nih.gov/pubmed/37865779
http://dx.doi.org/10.1186/s12974-023-02924-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590528/
https://www.ncbi.nlm.nih.gov/pubmed/37865779
http://dx.doi.org/10.1186/s12974-023-02924-5

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