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Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model
BACKGROUND: Acute graft-versus-host disease (aGVHD) is a major complication following hematopoietic stem cell transplantation (HSCT). OBJECTIVE: This study aimed to explore the risk factors for the incidence of aGVHD in patients post-HSCT. DESIGN: This was a retrospective study. METHODS: A total of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590544/ https://www.ncbi.nlm.nih.gov/pubmed/37872970 http://dx.doi.org/10.1177/20406207231205406 |
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author | Xue, Ling Song, Lin Yu, Xun Yang, Xiao Xia, Fan Ding, Xiaoliang Huang, Chenrong Wu, Depei Miao, Liyan |
author_facet | Xue, Ling Song, Lin Yu, Xun Yang, Xiao Xia, Fan Ding, Xiaoliang Huang, Chenrong Wu, Depei Miao, Liyan |
author_sort | Xue, Ling |
collection | PubMed |
description | BACKGROUND: Acute graft-versus-host disease (aGVHD) is a major complication following hematopoietic stem cell transplantation (HSCT). OBJECTIVE: This study aimed to explore the risk factors for the incidence of aGVHD in patients post-HSCT. DESIGN: This was a retrospective study. METHODS: A total of 407 patients were enrolled. The patients’ data were recorded from the medical records. The exposure of cyclosporine was estimated based on a population pharmacokinetics model. The occurrence of aGVHD was clinically graded and staged in severity from grades I to IV. A proportional odds model that estimated the cumulative probabilities of aGVHD was used to analyze the data using a nonlinear mixed-effects model. Then, the model parameters and plausibility were evaluated by bootstrap and visual predictive checks. RESULTS: The typical probabilities were 18.9% and 17.9% for grade II and grades III–IV, respectively. The incidence of grade II and grade III–IV aGVHD for human leukocyte antigen (HLA) haplo sibling donor patients was higher than that for HLA-matched donor patients. The incidence of grade II and grade III–IV aGVHD decreased with increasing early cyclosporine trough concentration; however, cyclosporine exposure was not associated with the incidence of aGVHD. CONCLUSION: HLA matching and early cyclosporine trough concentration were important factors for the occurrence of aGVHD. |
format | Online Article Text |
id | pubmed-10590544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-105905442023-10-23 Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model Xue, Ling Song, Lin Yu, Xun Yang, Xiao Xia, Fan Ding, Xiaoliang Huang, Chenrong Wu, Depei Miao, Liyan Ther Adv Hematol Original Research BACKGROUND: Acute graft-versus-host disease (aGVHD) is a major complication following hematopoietic stem cell transplantation (HSCT). OBJECTIVE: This study aimed to explore the risk factors for the incidence of aGVHD in patients post-HSCT. DESIGN: This was a retrospective study. METHODS: A total of 407 patients were enrolled. The patients’ data were recorded from the medical records. The exposure of cyclosporine was estimated based on a population pharmacokinetics model. The occurrence of aGVHD was clinically graded and staged in severity from grades I to IV. A proportional odds model that estimated the cumulative probabilities of aGVHD was used to analyze the data using a nonlinear mixed-effects model. Then, the model parameters and plausibility were evaluated by bootstrap and visual predictive checks. RESULTS: The typical probabilities were 18.9% and 17.9% for grade II and grades III–IV, respectively. The incidence of grade II and grade III–IV aGVHD for human leukocyte antigen (HLA) haplo sibling donor patients was higher than that for HLA-matched donor patients. The incidence of grade II and grade III–IV aGVHD decreased with increasing early cyclosporine trough concentration; however, cyclosporine exposure was not associated with the incidence of aGVHD. CONCLUSION: HLA matching and early cyclosporine trough concentration were important factors for the occurrence of aGVHD. SAGE Publications 2023-10-21 /pmc/articles/PMC10590544/ /pubmed/37872970 http://dx.doi.org/10.1177/20406207231205406 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Xue, Ling Song, Lin Yu, Xun Yang, Xiao Xia, Fan Ding, Xiaoliang Huang, Chenrong Wu, Depei Miao, Liyan Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
title | Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
title_full | Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
title_fullStr | Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
title_full_unstemmed | Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
title_short | Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
title_sort | assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model using a nonlinear mixed-effects model |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590544/ https://www.ncbi.nlm.nih.gov/pubmed/37872970 http://dx.doi.org/10.1177/20406207231205406 |
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