Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives

Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes....

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Autores principales: Chen, Haoran, Han, Zhongyu, Wang, Yi, Su, Junyan, Lin, Yumeng, Cheng, Xuhua, Liu, Wen, He, Jingyu, Fan, Yiyue, Chen, Liuyan, Zuo, Houdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590556/
https://www.ncbi.nlm.nih.gov/pubmed/37872954
http://dx.doi.org/10.2147/JIR.S432111
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author Chen, Haoran
Han, Zhongyu
Wang, Yi
Su, Junyan
Lin, Yumeng
Cheng, Xuhua
Liu, Wen
He, Jingyu
Fan, Yiyue
Chen, Liuyan
Zuo, Houdong
author_facet Chen, Haoran
Han, Zhongyu
Wang, Yi
Su, Junyan
Lin, Yumeng
Cheng, Xuhua
Liu, Wen
He, Jingyu
Fan, Yiyue
Chen, Liuyan
Zuo, Houdong
author_sort Chen, Haoran
collection PubMed
description Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes. Since its discovery, ferroptosis has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress and prospects, summarize the regulatory mechanisms of ferroptosis, and discuss the role of ferroptosis in the pathogenesis of bone-related diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and osteosarcoma (OS), as well as its therapeutic potential.
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spelling pubmed-105905562023-10-23 Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives Chen, Haoran Han, Zhongyu Wang, Yi Su, Junyan Lin, Yumeng Cheng, Xuhua Liu, Wen He, Jingyu Fan, Yiyue Chen, Liuyan Zuo, Houdong J Inflamm Res Review Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis is characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. Ferroptosis is involved in a variety of physiological and pathological processes. Since its discovery, ferroptosis has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress and prospects, summarize the regulatory mechanisms of ferroptosis, and discuss the role of ferroptosis in the pathogenesis of bone-related diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), and osteosarcoma (OS), as well as its therapeutic potential. Dove 2023-10-18 /pmc/articles/PMC10590556/ /pubmed/37872954 http://dx.doi.org/10.2147/JIR.S432111 Text en © 2023 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Chen, Haoran
Han, Zhongyu
Wang, Yi
Su, Junyan
Lin, Yumeng
Cheng, Xuhua
Liu, Wen
He, Jingyu
Fan, Yiyue
Chen, Liuyan
Zuo, Houdong
Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
title Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
title_full Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
title_fullStr Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
title_full_unstemmed Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
title_short Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
title_sort targeting ferroptosis in bone-related diseases: facts and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590556/
https://www.ncbi.nlm.nih.gov/pubmed/37872954
http://dx.doi.org/10.2147/JIR.S432111
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