Delivery of Plasmid DNA by Ionizable Lipid Nanoparticles to Induce CAR Expression in T Cells

INTRODUCTION: Chimeric antigen receptor (CAR) cell therapy represents a hallmark in cancer immunotherapy, with significant clinical results in the treatment of hematological tumors. However, current approved methods to engineer T cells to express CAR use viral vectors, which are integrative and have...

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Detalles Bibliográficos
Autores principales: Prazeres, Pedro Henrique Dias Moura, Ferreira, Heloísa, Costa, Pedro Augusto Carvalho, da Silva, Walison, Alves, Marco Túllio, Padilla, Marshall, Thatte, Ajay, Santos, Anderson Kenedy, Lobo, Anderson Oliveira, Sabino, Adriano, Del Puerto, Helen Lima, Mitchell, Michael J, Guimaraes, Pedro Pires Goulart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590593/
https://www.ncbi.nlm.nih.gov/pubmed/37873551
http://dx.doi.org/10.2147/IJN.S424723

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