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Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study

Human adenoviruses (HAdVs) can cause acute hepatitis in immunocompromised patients. However, it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children. In this study, the liver function test (LFT) results were retrospectively analyzed among children hospitalized (age <...

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Autores principales: Tian, Xingui, Li, Xiao, Qiu, Shuyan, Zhou, Rong, Liu, Wenkuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590690/
https://www.ncbi.nlm.nih.gov/pubmed/37524229
http://dx.doi.org/10.1016/j.virs.2023.07.007
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author Tian, Xingui
Li, Xiao
Qiu, Shuyan
Zhou, Rong
Liu, Wenkuan
author_facet Tian, Xingui
Li, Xiao
Qiu, Shuyan
Zhou, Rong
Liu, Wenkuan
author_sort Tian, Xingui
collection PubMed
description Human adenoviruses (HAdVs) can cause acute hepatitis in immunocompromised patients. However, it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children. In this study, the liver function test (LFT) results were retrospectively analyzed among children hospitalized (age <14 years) between January 2016 and October 2019 for acute respiratory infection caused by adenoviruses. Alanine transaminase (ALT) and aspartate aminotransferase (AST) levels were elevated in 7.74% and 46.89% of patients, respectively. All patients with >2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or HAdV-55. Significantly higher levels of ALT, AST, γ-glutamyl transpeptidase (γ-GT), and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection group. HAdV-55 infection led to significantly higher γ-GT, total bilirubin, and direct bilirubin levels than the other infection types. The records of four patients with serial monitoring of the LFT results were further analyzed. Multiple indicators remained abnormal during the entire hospitalization in these patients. These results indicate that HAdV infection is often accompanied by abnormal liver function, and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children.
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spelling pubmed-105906902023-10-23 Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study Tian, Xingui Li, Xiao Qiu, Shuyan Zhou, Rong Liu, Wenkuan Virol Sin Research Article Human adenoviruses (HAdVs) can cause acute hepatitis in immunocompromised patients. However, it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children. In this study, the liver function test (LFT) results were retrospectively analyzed among children hospitalized (age <14 years) between January 2016 and October 2019 for acute respiratory infection caused by adenoviruses. Alanine transaminase (ALT) and aspartate aminotransferase (AST) levels were elevated in 7.74% and 46.89% of patients, respectively. All patients with >2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or HAdV-55. Significantly higher levels of ALT, AST, γ-glutamyl transpeptidase (γ-GT), and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection group. HAdV-55 infection led to significantly higher γ-GT, total bilirubin, and direct bilirubin levels than the other infection types. The records of four patients with serial monitoring of the LFT results were further analyzed. Multiple indicators remained abnormal during the entire hospitalization in these patients. These results indicate that HAdV infection is often accompanied by abnormal liver function, and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children. Wuhan Institute of Virology, Chinese Academy of Sciences 2023-07-29 /pmc/articles/PMC10590690/ /pubmed/37524229 http://dx.doi.org/10.1016/j.virs.2023.07.007 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Tian, Xingui
Li, Xiao
Qiu, Shuyan
Zhou, Rong
Liu, Wenkuan
Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
title Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
title_full Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
title_fullStr Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
title_full_unstemmed Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
title_short Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
title_sort abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590690/
https://www.ncbi.nlm.nih.gov/pubmed/37524229
http://dx.doi.org/10.1016/j.virs.2023.07.007
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