Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers

KRAS-TP53 co-mutation is strongly associated with poor prognosis and high malignancy in gastrointestinal cancers. Therefore, a novel approach to oncotherapy may lie in combination therapy targeting both KRAS and TP53. Herein, we present a novel self-assembled nanoparticle (HA-TPP/A) that are functio...

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Detalles Bibliográficos
Autores principales: Mei, Yong, Qin, Xiaohua, Yang, Zhenyu, Song, Shiyao, Liu, Xiaoting, Wu, Chong, Qian, Jieying, Huang, Xiaowan, Zhang, Yunjiao, He, Weiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590736/
https://www.ncbi.nlm.nih.gov/pubmed/37876556
http://dx.doi.org/10.1016/j.bioactmat.2023.10.003

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