Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice

Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic steatosis increases. Here, we show that WD40 repe...

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Detalles Bibliográficos
Autores principales: Yao, Zhenyu, Gong, Ying, Chen, Wenbin, Shao, Shanshan, Song, Yongfeng, Guo, Honglin, Li, Qihang, Liu, Sijin, Wang, Ximing, Zhang, Zhenhai, Wang, Qian, Xu, Yunyun, Wu, Yingjie, Wan, Qiang, Zhao, Xinya, Xuan, Qiuhui, Wang, Dawei, Lin, Xiaoyan, Xu, Jiawen, Liu, Jun, Proud, Christopher G., Wang, Xuemin, Yang, Rui, Fu, Lili, Niu, Shaona, Kong, Junjie, Gao, Ling, Bo, Tao, Zhao, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590755/
https://www.ncbi.nlm.nih.gov/pubmed/37735236
http://dx.doi.org/10.1038/s42255-023-00896-7

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