Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance

In human cancer, activating mutations in the KEAP1-NRF2 pathway are frequently observed, and positively selected for, as they confer the cytoprotective functions of the transcription factor NRF2 on the cancer cells. This results in the development of aggressive tumours which are resistant to treatme...

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Detalles Bibliográficos
Autores principales: Baird, Liam, Yamamoto, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590843/
https://www.ncbi.nlm.nih.gov/pubmed/37839356
http://dx.doi.org/10.1016/j.redox.2023.102904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590843/
https://www.ncbi.nlm.nih.gov/pubmed/37839356
http://dx.doi.org/10.1016/j.redox.2023.102904

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