A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials

BACKGROUND: Interventional trials that evaluate treatment effects using surrogate endpoints have become increasingly common. This paper describes four linked empirical studies and the development of a framework for defining, interpreting and reporting surrogate endpoints in trials. METHODS: As part...

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Detalles Bibliográficos
Autores principales: Ciani, Oriana, Manyara, Anthony M., Davies, Philippa, Stewart, Derek, Weir, Christopher J., Young, Amber E., Blazeby, Jane, Butcher, Nancy J., Bujkiewicz, Sylwia, Chan, An-Wen, Dawoud, Dalia, Offringa, Martin, Ouwens, Mario, Hróbjartssson, Asbjørn, Amstutz, Alain, Bertolaccini, Luca, Bruno, Vito Domenico, Devane, Declan, Faria, Christina D.C.M., Gilbert, Peter B., Harris, Ray, Lassere, Marissa, Marinelli, Lucio, Markham, Sarah, Powers, John H., Rezaei, Yousef, Richert, Laura, Schwendicke, Falk, Tereshchenko, Larisa G., Thoma, Achilles, Turan, Alparslan, Worrall, Andrew, Christensen, Robin, Collins, Gary S., Ross, Joseph S., Taylor, Rod S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590868/
https://www.ncbi.nlm.nih.gov/pubmed/37877001
http://dx.doi.org/10.1016/j.eclinm.2023.102283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590868/
https://www.ncbi.nlm.nih.gov/pubmed/37877001
http://dx.doi.org/10.1016/j.eclinm.2023.102283

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