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Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection
The present review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection. In the first part, the continued need for cardioprotection beyond that by rapid reperfusion of acute myocardial infarction is emphasized. Then...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590874/ https://www.ncbi.nlm.nih.gov/pubmed/37839355 http://dx.doi.org/10.1016/j.redox.2023.102894 |
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author | Heusch, Gerd Andreadou, Ioanna Bell, Robert Bertero, Edoardo Botker, Hans-Erik Davidson, Sean M. Downey, James Eaton, Philip Ferdinandy, Peter Gersh, Bernard J. Giacca, Mauro Hausenloy, Derek J. Ibanez, Borja Krieg, Thomas Maack, Christoph Schulz, Rainer Sellke, Frank Shah, Ajay M. Thiele, Holger Yellon, Derek M. Di Lisa, Fabio |
author_facet | Heusch, Gerd Andreadou, Ioanna Bell, Robert Bertero, Edoardo Botker, Hans-Erik Davidson, Sean M. Downey, James Eaton, Philip Ferdinandy, Peter Gersh, Bernard J. Giacca, Mauro Hausenloy, Derek J. Ibanez, Borja Krieg, Thomas Maack, Christoph Schulz, Rainer Sellke, Frank Shah, Ajay M. Thiele, Holger Yellon, Derek M. Di Lisa, Fabio |
author_sort | Heusch, Gerd |
collection | PubMed |
description | The present review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection. In the first part, the continued need for cardioprotection beyond that by rapid reperfusion of acute myocardial infarction is emphasized. Then, pathomechanisms of myocardial ischemia/reperfusion to the myocardium and the coronary circulation and the different modes of cell death in myocardial infarction are characterized. Different mechanical and pharmacological interventions to protect the ischemic/reperfused myocardium in elective percutaneous coronary interventions and coronary artery bypass grafting, in acute myocardial infarction and in cardiotoxicity from cancer therapy are detailed. The second part keeps the focus on ROS providing a comprehensive overview of molecular and cellular mechanisms involved in ischemia/reperfusion injury. Starting from mitochondria as the main sources and targets of ROS in ischemic/reperfused myocardium, a complex network of cellular and extracellular processes is discussed, including relationships with Ca(2+) homeostasis, thiol group redox balance, hydrogen sulfide modulation, cross-talk with NAPDH oxidases, exosomes, cytokines and growth factors. While mechanistic insights are needed to improve our current therapeutic approaches, advancements in knowledge of ROS-mediated processes indicate that detrimental facets of oxidative stress are opposed by ROS requirement for physiological and protective reactions. This inevitable contrast is likely to underlie unsuccessful clinical trials and limits the development of novel cardioprotective interventions simply based upon ROS removal. |
format | Online Article Text |
id | pubmed-10590874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105908742023-10-24 Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection Heusch, Gerd Andreadou, Ioanna Bell, Robert Bertero, Edoardo Botker, Hans-Erik Davidson, Sean M. Downey, James Eaton, Philip Ferdinandy, Peter Gersh, Bernard J. Giacca, Mauro Hausenloy, Derek J. Ibanez, Borja Krieg, Thomas Maack, Christoph Schulz, Rainer Sellke, Frank Shah, Ajay M. Thiele, Holger Yellon, Derek M. Di Lisa, Fabio Redox Biol Review Article The present review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection. In the first part, the continued need for cardioprotection beyond that by rapid reperfusion of acute myocardial infarction is emphasized. Then, pathomechanisms of myocardial ischemia/reperfusion to the myocardium and the coronary circulation and the different modes of cell death in myocardial infarction are characterized. Different mechanical and pharmacological interventions to protect the ischemic/reperfused myocardium in elective percutaneous coronary interventions and coronary artery bypass grafting, in acute myocardial infarction and in cardiotoxicity from cancer therapy are detailed. The second part keeps the focus on ROS providing a comprehensive overview of molecular and cellular mechanisms involved in ischemia/reperfusion injury. Starting from mitochondria as the main sources and targets of ROS in ischemic/reperfused myocardium, a complex network of cellular and extracellular processes is discussed, including relationships with Ca(2+) homeostasis, thiol group redox balance, hydrogen sulfide modulation, cross-talk with NAPDH oxidases, exosomes, cytokines and growth factors. While mechanistic insights are needed to improve our current therapeutic approaches, advancements in knowledge of ROS-mediated processes indicate that detrimental facets of oxidative stress are opposed by ROS requirement for physiological and protective reactions. This inevitable contrast is likely to underlie unsuccessful clinical trials and limits the development of novel cardioprotective interventions simply based upon ROS removal. Elsevier 2023-10-06 /pmc/articles/PMC10590874/ /pubmed/37839355 http://dx.doi.org/10.1016/j.redox.2023.102894 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Heusch, Gerd Andreadou, Ioanna Bell, Robert Bertero, Edoardo Botker, Hans-Erik Davidson, Sean M. Downey, James Eaton, Philip Ferdinandy, Peter Gersh, Bernard J. Giacca, Mauro Hausenloy, Derek J. Ibanez, Borja Krieg, Thomas Maack, Christoph Schulz, Rainer Sellke, Frank Shah, Ajay M. Thiele, Holger Yellon, Derek M. Di Lisa, Fabio Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
title | Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
title_full | Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
title_fullStr | Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
title_full_unstemmed | Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
title_short | Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
title_sort | health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590874/ https://www.ncbi.nlm.nih.gov/pubmed/37839355 http://dx.doi.org/10.1016/j.redox.2023.102894 |
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