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Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that disrupts cognitive function and severely affects the quality of life. Existing drugs only improve cognitive function and provide temporary relief of symptoms but do not stop or delay disease progression. Recently, natural medic...

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Detalles Bibliográficos
Autores principales: Liu, Nanyang, Ruan, Juanjuan, Li, Hao, Fu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590901/
https://www.ncbi.nlm.nih.gov/pubmed/37877008
http://dx.doi.org/10.3389/fnins.2023.1112435
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author Liu, Nanyang
Ruan, Juanjuan
Li, Hao
Fu, Jianhua
author_facet Liu, Nanyang
Ruan, Juanjuan
Li, Hao
Fu, Jianhua
author_sort Liu, Nanyang
collection PubMed
description Alzheimer’s disease (AD) is a progressive neurodegenerative disease that disrupts cognitive function and severely affects the quality of life. Existing drugs only improve cognitive function and provide temporary relief of symptoms but do not stop or delay disease progression. Recently, natural medicines, especially Chinese herbal medicines, have gained attention in the treatment of AD due to their antioxidant, anti-inflammatory, and neuroprotective effects. However, conventional oral dosage forms lack brain specificity and have side effects that lead to poor patient compliance. Utilizing nanomedicine is a promising approach to improve brain specificity, bioavailability, and patient compliance. This review evaluates recent advances in the treatment of AD with nanoparticles containing various natural medicines. This review highlights that nanoparticles containing natural medicines are a promising strategy for the treatment of AD. It is believed that this technology can be translated into the clinic, thereby providing opportunities for AD patients to participate in social activities.
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spelling pubmed-105909012023-10-24 Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease Liu, Nanyang Ruan, Juanjuan Li, Hao Fu, Jianhua Front Neurosci Neuroscience Alzheimer’s disease (AD) is a progressive neurodegenerative disease that disrupts cognitive function and severely affects the quality of life. Existing drugs only improve cognitive function and provide temporary relief of symptoms but do not stop or delay disease progression. Recently, natural medicines, especially Chinese herbal medicines, have gained attention in the treatment of AD due to their antioxidant, anti-inflammatory, and neuroprotective effects. However, conventional oral dosage forms lack brain specificity and have side effects that lead to poor patient compliance. Utilizing nanomedicine is a promising approach to improve brain specificity, bioavailability, and patient compliance. This review evaluates recent advances in the treatment of AD with nanoparticles containing various natural medicines. This review highlights that nanoparticles containing natural medicines are a promising strategy for the treatment of AD. It is believed that this technology can be translated into the clinic, thereby providing opportunities for AD patients to participate in social activities. Frontiers Media S.A. 2023-10-09 /pmc/articles/PMC10590901/ /pubmed/37877008 http://dx.doi.org/10.3389/fnins.2023.1112435 Text en Copyright © 2023 Liu, Ruan, Li and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Nanyang
Ruan, Juanjuan
Li, Hao
Fu, Jianhua
Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
title Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
title_full Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
title_fullStr Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
title_full_unstemmed Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
title_short Nanoparticles loaded with natural medicines for the treatment of Alzheimer’s disease
title_sort nanoparticles loaded with natural medicines for the treatment of alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590901/
https://www.ncbi.nlm.nih.gov/pubmed/37877008
http://dx.doi.org/10.3389/fnins.2023.1112435
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