Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner

BACKGROUND: Crohn’s disease (CD) is a complex and poorly understood myeloid-mediated disorder. Genetic variants with loss of function in the NOD2 gene confer an increased susceptibility to ileal CD. While Nod2 in myeloid cells may confer protection against T-cell mediated ileopathy, it remains uncle...

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Detalles Bibliográficos
Autores principales: Chauvin, Camille, Radulovic, Katarina, Boulard, Olivier, Delacre, Myriam, Waldschmitt, Nadine, Régnier, Paul, Legris, Gauthier, Bouchez, Clément, Sleimi, Mohamed-Yassine, Rosenstiel, Philip, Darrasse-Jèze, Guillaume, Chamaillard, Mathias, Poulin, Lionel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590911/
https://www.ncbi.nlm.nih.gov/pubmed/37876927
http://dx.doi.org/10.3389/fimmu.2023.1252979

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