Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice

The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine, which have been shown to reduce RNA sensing by th...

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Detalles Bibliográficos
Autores principales: Wang, Ziyin, Jacobus, Egon J., Stirling, David C., Krumm, Stefanie, Flight, Katie E., Cunliffe, Robert F., Mottl, Jonathan, Singh, Charanjit, Mosscrop, Lucy G., Santiago, Leticia Aragão, Vogel, Annette B., Kariko, Katalin, Sahin, Ugur, Erbar, Stephanie, Tregoning, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591005/
https://www.ncbi.nlm.nih.gov/pubmed/37876532
http://dx.doi.org/10.1016/j.omtn.2023.102045

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