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An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing

The four-subunit negative elongation factor (NELF) complex mediates RNA polymerase II (Pol II) pausing at promoter-proximal regions. Ablation of individual NELF subunits destabilizes the NELF complex and causes cell lethality, leading to the prevailing concept that NELF-mediated Pol II pausing is es...

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Detalles Bibliográficos
Autores principales:	Pan, Haihui, Cheng, Xiaolong, Rodríguez, Pedro Felipe Gardeazábal, Zhang, Xiaowen, Chung, Inhee, Jin, Victor X., Li, Wei, Hu, Yanfen, Li, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591015/ https://www.ncbi.nlm.nih.gov/pubmed/37717699 http://dx.doi.org/10.1016/j.jbc.2023.105259

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