Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity

Targeted therapies are effective in treating cancer, but success depends on identifying cancer vulnerabilities. In our study, we utilize small RNA sequencing to examine the impact of pathway activation on microRNA (miRNA) expression patterns. Interestingly, we discover that miRNAs capable of inhibit...

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Detalles Bibliográficos
Autores principales: Wurm, Alexander A., Brilloff, Silke, Kolovich, Sofia, Schäfer, Silvia, Rahimian, Elahe, Kufrin, Vida, Bill, Marius, Carrero, Zunamys I., Drukewitz, Stephan, Krüger, Alexander, Hüther, Melanie, Uhrig, Sebastian, Oster, Sandra, Westphal, Dana, Meier, Friedegund, Pfütze, Katrin, Hübschmann, Daniel, Horak, Peter, Kreutzfeldt, Simon, Richter, Daniela, Schröck, Evelin, Baretton, Gustavo, Heining, Christoph, Möhrmann, Lino, Fröhling, Stefan, Ball, Claudia R., Glimm, Hanno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591033/
https://www.ncbi.nlm.nih.gov/pubmed/37734378
http://dx.doi.org/10.1016/j.xcrm.2023.101200

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